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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:deglymidodrine
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Accession:CHEBI:73248 term browser browse the term
Definition:An aromatic ether that is 1,4-dimethoxybenzene which is substituted at position 2 by a 2-amino-1-hydroxyethyl group. The immediate and active metabolite of midrodine, it is a direct-acting sympathomimetic with selective alpha-adrenergic agonist activity. Midrodine is used (generally as its hydrochloride salt) as a prodrug for deglymidodrine, which acts as a peripheral vasoconstrictor in the treatment of certain hypotensive states.
Synonyms:related_synonym: (+-)-2-amino-1-(2,5-dimethoxyphenyl)ethanol;   1-(2',5'-dimethoxyphenyl)aminoethanol;   Formula=C10H15NO3;   InChI=1S/C10H15NO3/c1-13-7-3-4-10(14-2)8(5-7)9(12)6-11/h3-5,9,12H,6,11H2,1-2H3;   InChIKey=VFRCNXKYZVQYLX-UHFFFAOYSA-N;   SMILES=COc1ccc(OC)c(c1)C(O)CN;   ST-1059;   alpha-(aminomethyl)-2,5-dimethoxybenzenemethanol;   de-glymidodrine;   desglymidodrine;   rac-2-amino-1-(2,5-dimethoxyphenyl)ethanol
 xref: CAS:3600-87-1;   PMID:15537169;   PMID:16242885;   PMID:23051063;   Reaxys:3262168


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midodrine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc47a1 solute carrier family 47 member 1 multiple interactions ISO Midodrine inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:46,034,115...46,088,617
Ensembl chr10:46,034,122...46,087,637 		JBrowse link
G Slc47a2 solute carrier family 47 member 2 multiple interactions ISO Midodrine inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:45,990,806...46,033,937
Ensembl chr10:45,991,095...46,033,904 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19841
    role 19817
      biological role 19815
        pharmacological role 19058
          neurotransmitter agent 16741
            adrenergic agent 9184
              sympathomimetic agent 5581
                deglymidodrine 2
                  midodrine 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19841
    subatomic particle 19839
      composite particle 19839
        hadron 19839
          baryon 19839
            nucleon 19839
              atomic nucleus 19839
                atom 19839
                  main group element atom 19789
                    main group molecular entity 19789
                      s-block molecular entity 19626
                        hydrogen molecular entity 19613
                          hydrides 19120
                            inorganic hydride 18118
                              pnictogen hydride 18107
                                nitrogen hydride 18014
                                  azane 17824
                                    ammonia 17823
                                      organic amino compound 17823
                                        primary amino compound 9311
                                          deglymidodrine 2
                                            midodrine 2
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