Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:diphenylpyraline
go back to main search page
Accession:CHEBI:59788 term browser browse the term
Definition:A member of the class of piperidines that is the benzhydryl ether derivative of 1-methyl-4-hydroxypiperidine. A sedating antihistamine, it is used as the hydrochloride for the symptomatic relief of allergic conditions including rhinitis and hay fever, and in pruritic skin disorders. It is also used as the teoclate salt (piprinhydrinate) as an ingredient in compound preparations for the symptomatic relief of coughs and the common cold.
Synonyms:exact_synonym: 4-(diphenylmethoxy)-1-methylpiperidine
 related_synonym: 1-methyl-4-hydroxypiperidine benzhydryl ether;   1-methyl-4-piperidyl benzhydryl ether;   4-(benzhydryloxy)-1-methylpiperidine;   4-(benzhydryloxy)-N-methylpiperidine;   Formula=C19H23NO;   InChI=1S/C19H23NO/c1-20-14-12-18(13-15-20)21-19(16-8-4-2-5-9-16)17-10-6-3-7-11-17/h2-11,18-19H,12-15H2,1H3;   InChIKey=OWQUZNMMYNAXSL-UHFFFAOYSA-N;   SMILES=CN1CCC(CC1)OC(c1ccccc1)c1ccccc1;   difenilpiralina;   diphenylpyralamine;   diphenylpyralinum
 xref: Beilstein:245467;   CAS:147-20-6;   DrugBank:DB01146;   Drug_Central:920;   HMDB:HMDB0015277;   KEGG:D07862;   LINCS:LSM-5385
 xref_mesh: MESH:C009871
 xref: PMID:14039;   PMID:15627433;   PMID:22445882;   Patent:US2479843;   Reaxys:245467;   Wikipedia:Diphenylpyraline


show annotations for term's descendants           Sort by:
diphenylpyraline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hrh1 histamine receptor H 1 multiple interactions ISO diphenylpyraline binds to and results in increased activity of HRH1 protein; diphenylpyraline inhibits the reaction [Pyrilamine binds to HRH1 protein] CTD PMID:1912125 NCBI chr 4:147,564,963...147,649,353
Ensembl chr 4:147,645,995...147,647,455 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO diphenylpyraline results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19834
    role 19810
      biological role 19808
        pharmacological role 19055
          antagonist 17244
            histamine antagonist 4893
              H1-receptor antagonist 4146
                diphenylpyraline 2
                  diphenylpyraline hydrochloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19834
    subatomic particle 19832
      composite particle 19832
        hadron 19832
          baryon 19832
            nucleon 19832
              atomic nucleus 19832
                atom 19832
                  main group element atom 19782
                    main group molecular entity 19782
                      s-block molecular entity 19620
                        hydrogen molecular entity 19607
                          hydrides 19113
                            inorganic hydride 18117
                              pnictogen hydride 18106
                                nitrogen hydride 18013
                                  azane 17821
                                    ammonia 17820
                                      organic amino compound 17820
                                        tertiary amino compound 10138
                                          tertiary amine 641
                                            diphenylpyraline 2
                                              diphenylpyraline hydrochloride 0
paths to the root