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G |
Cyp2d4 |
cytochrome P450, family 2, subfamily d, polypeptide 4 |
decreases activity |
ISO |
Cinacalcet results in decreased activity of CYP2D6 protein |
CTD |
PMID:16680561 |
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NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
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G |
Kcnh2 |
potassium voltage-gated channel subfamily H member 2 |
decreases activity |
ISO |
Cinacalcet results in decreased activity of KCNH2 protein |
CTD |
PMID:28551711 |
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NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
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G |
Klf2 |
KLF transcription factor 2 |
increases expression decreases ubiquitination multiple interactions |
ISO |
Cinacalcet results in increased expression of KLF2 protein Cinacalcet results in decreased ubiquitination of KLF2 protein [Cinacalcet inhibits the reaction [Adenine results in increased expression of TRAF2 protein]] which results in decreased ubiquitination of and results in decreased degradation of KLF2 protein; [Cinacalcet results in decreased expression of TRAF2 protein] which results in decreased ubiquitination of KLF2 protein; Cinacalcet inhibits the reaction [Adenine results in decreased expression of KLF2 protein]; TRAF2 protein inhibits the reaction [Cinacalcet results in increased expression of KLF2 protein] |
CTD |
PMID:35635602 |
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NCBI chr16:17,521,107...17,523,739
Ensembl chr16:17,514,552...17,523,944
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G |
Pth |
parathyroid hormone |
decreases expression decreases secretion multiple interactions |
ISO |
Cinacalcet results in decreased expression of PTH protein Cinacalcet results in decreased secretion of PTH protein [Cinacalcet co-treated with Vitamin D] results in decreased expression of PTH protein |
CTD |
PMID:17060004 PMID:18256372 PMID:21541686 PMID:22118402 |
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NCBI chr 1:167,508,121...167,511,530
Ensembl chr 1:167,508,598...167,511,530
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G |
Traf2 |
Tnf receptor-associated factor 2 |
multiple interactions decreases expression |
ISO |
[Cinacalcet inhibits the reaction [Adenine results in increased expression of TRAF2 protein]] which results in decreased ubiquitination of and results in decreased degradation of KLF2 protein; [Cinacalcet results in decreased expression of TRAF2 protein] which results in decreased ubiquitination of KLF2 protein; Cinacalcet inhibits the reaction [Adenine results in increased expression of TRAF2 protein]; TRAF2 protein inhibits the reaction [Cinacalcet results in increased expression of KLF2 protein] Cinacalcet results in decreased expression of TRAF2 mRNA; Cinacalcet results in decreased expression of TRAF2 protein |
CTD |
PMID:35635602 |
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NCBI chr 3:8,341,950...8,366,609
Ensembl chr 3:8,341,951...8,366,538
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