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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:cefixime
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Accession:CHEBI:472657 term browser browse the term
Definition:A third-generation cephalosporin antibiotic bearing vinyl and (2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-[(carboxymethoxy)imino]acetamido groups at positions 3 and 7, respectively, of the cephem skeleton. It is used in the treatment of gonorrhoea, tonsilitis, pharyngitis, bronchitis, and urinary tract infections.
Synonyms:exact_synonym: 7beta-{(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-[(carboxymethoxy)imino]acetamido}-3-ethenyl-3,4-didehydrocepham-4-carboxylic acid
 related_synonym: (-)-cefixim;   (6R,7R)-7-({(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-[(carboxymethoxy)imino]acetyl}amino)-3-ethenyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;   Formula=C16H15N5O7S2;   InChI=1S/C16H15N5O7S2/c1-2-6-4-29-14-10(13(25)21(14)11(6)15(26)27)19-12(24)9(20-28-3-8(22)23)7-5-30-16(17)18-7/h2,5,10,14H,1,3-4H2,(H2,17,18)(H,19,24)(H,22,23)(H,26,27)/b20-9-/t10-,14-/m1/s1;   InChIKey=OKBVVJOGVLARMR-QSWIMTSFSA-N;   SMILES=[H][C@]12SCC(C=C)=C(N1C(=O)[C@H]2NC(=O)C(=N/OCC(O)=O)\\c1csc(N)n1)C(O)=O;   cefixima;   cefiximum
 alt_id: CHEBI:3487
 xref: Beilstein:6025058;   CAS:79350-37-1;   DrugBank:DB00671;   Drug_Central:537;   KEGG:C06881;   KEGG:D00258
 xref_mesh: MESH:D020682
 xref: PMID:17116681;   PMID:29017833;   Patent:EP30630;   Patent:US4409214


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cefixime term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rab8a RAB8A, member RAS oncogene family multiple interactions
increases uptake		 ISO [RAB8A protein results in increased localization of SLC15A1 protein] which results in increased uptake of Cefixime
RAB8A protein results in increased uptake of Cefixime		 CTD PMID:19074526 NCBI chr16:17,654,027...17,675,385
Ensembl chr16:17,654,034...17,675,678 		JBrowse link
G Slc15a1 solute carrier family 15 member 1 multiple interactions
increases uptake		 ISO [RAB8A protein results in increased localization of SLC15A1 protein] which results in increased uptake of Cefixime
SLC15A1 protein results in increased uptake of Cefixime		 CTD PMID:19074526 NCBI chr15:98,537,641...98,582,544
Ensembl chr15:98,537,641...98,582,545 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19838
    role 19814
      biological role 19812
        antimicrobial agent 18164
          antibacterial agent 15631
            antibacterial drug 4413
              cefixime 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19838
    subatomic particle 19836
      composite particle 19836
        hadron 19836
          baryon 19836
            nucleon 19836
              atomic nucleus 19836
                atom 19836
                  main group element atom 19786
                    p-block element atom 19786
                      carbon group element atom 19734
                        carbon atom 19731
                          organic molecular entity 19731
                            heteroorganic entity 19488
                              organochalcogen compound 19251
                                organooxygen compound 19168
                                  carbon oxoacid 18637
                                    carboxylic acid 18634
                                      carboacyl group 17696
                                        univalent carboacyl group 17696
                                          carbamoyl group 17546
                                            carboxamide 17546
                                              lactam 8392
                                                beta-lactam 830
                                                  beta-lactam antibiotic 815
                                                    cephem 551
                                                      cephalosporin 550
                                                        cefixime 2
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