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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:cephalexin
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Accession:CHEBI:3534 term browser browse the term
Definition:A semisynthetic first-generation cephalosporin antibiotic having methyl and beta-(2R)-2-amino-2-phenylacetamido groups at the 3- and 7- of the cephem skeleton, respectively. It is effective against both Gram-negative and Gram-positive organisms, and is used for treatment of infections of the skin, respiratory tract and urinary tract.
Synonyms:exact_synonym: 7beta-[(2R)-2-amino-2-phenylacetamido]-3-methyl-3,4-didehydrocepham-4-carboxylic acid
 related_synonym: (6R,7R)-7-{[(2R)-2-amino-2-phenylacetyl]amino}-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;   7-(D-alpha-Aminophenylacetamido)desacetoxycephalosporanic acid;   7-beta-(D-alpha-Amino-alpha-phenylacetylamino)-3-methyl-3-cephem-4-carboxylic acid;   CEX;   Cefalexin;   Celexin;   Cepastar;   Cepexin;   Cephacillin;   Ceporexin;   Formula=C16H17N3O4S;   InChI=1S/C16H17N3O4S/c1-8-7-24-15-11(14(21)19(15)12(8)16(22)23)18-13(20)10(17)9-5-3-2-4-6-9/h2-6,10-11,15H,7,17H2,1H3,(H,18,20)(H,22,23)/t10-,11-,15-/m1/s1;   InChIKey=ZAIPMKNFIOOWCQ-UEKVPHQBSA-N;   SMILES=[H][C@]12SCC(C)=C(N1C(=O)[C@H]2NC(=O)[C@H](N)c1ccccc1)C(O)=O;   cefalexina;   cefalexine;   cefalexinum
 xref: Beilstein:965503;   CAS:15686-71-2;   DrugBank:DB00567;   Drug_Central:571;   HMDB:HMDB0014707;   KEGG:C06895;   KEGG:D00263;   LINCS:LSM-5957
 xref_mesh: MESH:D002506
 xref: PMID:10930630;   PMID:12569987;   PMID:12833570;   PMID:1384868;   PMID:2083978;   PMID:22559990;   PMID:23061564;   PMID:23457080;   PMID:23545436;   PMID:23688276;   PMID:23811740;   PMID:24268227;   PMID:24548092;   PMID:29017833;   Patent:US3275626;   Patent:US3507861;   Reaxys:4238892;   VSDB:1791;   Wikipedia:Cefalexin
 cyclic_relationship: is_conjugate_acid_of CHEBI:59392


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cephalexin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RT1-Ha RT1 class II, locus Ha affects expression ISO Cephalexin affects the expression of HLA-DPA1 mRNA CTD PMID:25811541 NCBI chr20:4,760,631...4,770,662
Ensembl chr20:4,760,118...4,770,244 		JBrowse link
G Slc15a1 solute carrier family 15 member 1 increases transport EXP SLC15A1 protein results in increased transport of Cephalexin CTD PMID:19881305 NCBI chr15:98,537,641...98,582,544
Ensembl chr15:98,537,641...98,582,545 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19841
    role 19817
      biological role 19815
        antimicrobial agent 18166
          antibacterial agent 15629
            antibacterial drug 4413
              cephalexin 2
                cefalexin pivoxil 0
                cephalexin monohydrate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19841
    subatomic particle 19839
      composite particle 19839
        hadron 19839
          baryon 19839
            nucleon 19839
              atomic nucleus 19839
                atom 19839
                  main group element atom 19789
                    p-block element atom 19789
                      carbon group element atom 19737
                        carbon atom 19733
                          organic molecular entity 19733
                            heteroorganic entity 19492
                              organochalcogen compound 19255
                                organooxygen compound 19172
                                  carbon oxoacid 18641
                                    carboxylic acid 18638
                                      carboacyl group 17698
                                        univalent carboacyl group 17698
                                          carbamoyl group 17548
                                            carboxamide 17548
                                              lactam 8390
                                                beta-lactam 830
                                                  beta-lactam antibiotic 815
                                                    cephem 551
                                                      cephalosporin 550
                                                        cephalexin 2
                                                          cefalexin pivoxil 0
                                                          cephalexin monohydrate 0
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