Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:(5-hydroxyindol-3-yl)acetic acid
go back to main search page
Accession:CHEBI:27823 term browser browse the term
Definition:A member of the class of indole-3-acetic acids that is indole-3-acetic acid substituted by a hydroxy group at C-5.
Synonyms:exact_synonym: (5-hydroxy-1H-indol-3-yl)acetic acid
 related_synonym: 5-HIAA;   5-Hydroxy-1H-indole-3-acetic acid;   5-Hydroxyindol-3-ylacetic acid;   5-Hydroxyindole-3-acetic acid;   5-Hydroxyindoleacetic acid;   Formula=C10H9NO3;   InChI=1S/C10H9NO3/c12-7-1-2-9-8(4-7)6(5-11-9)3-10(13)14/h1-2,4-5,11-12H,3H2,(H,13,14);   InChIKey=DUUGKQCEGZLZNO-UHFFFAOYSA-N;   SMILES=OC(=O)Cc1c[nH]c2ccc(O)cc12
 alt_id: CHEBI:20585;   CHEBI:2071
 xref: Beilstein:168797;   CAS:54-16-0;   HMDB:HMDB0000763;   KEGG:C05635;   KNApSAcK:C00000104
 xref_mesh: MESH:D006897
 xref: MetaCyc:5-HYDROXYINDOLE_ACETATE;   PMID:11063613;   PMID:11113939;   PMID:22770225;   Reaxys:168797;   Wikipedia:5-Hydroxyindoleacetic_acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:62622


show annotations for term's descendants           Sort by:
(5-hydroxyindol-3-yl)acetic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb2 adrenoceptor beta 2 multiple interactions EXP [Albuterol binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Hydroxyindoleacetic Acid CTD PMID:2463453 NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512 		JBrowse link
G Maoa monoamine oxidase A multiple interactions EXP [MAOA protein results in increased hydroxylation of Serotonin] which results in increased chemical synthesis of Hydroxyindoleacetic Acid CTD PMID:32243540 NCBI chr  X:6,032,172...6,098,308
Ensembl chr  X:6,030,795...6,099,593 		JBrowse link
G Otc ornithine transcarbamylase affects abundance
multiple interactions		 ISO OTC gene mutant form affects the abundance of Hydroxyindoleacetic Acid
Sodium Benzoate affects the reaction [OTC gene mutant form affects the abundance of Hydroxyindoleacetic Acid]		 CTD PMID:3374991 NCBI chr  X:12,453,834...12,529,954
Ensembl chr  X:12,453,834...12,566,918 		JBrowse link
G Tdo2 tryptophan 2,3-dioxygenase increases abundance ISO TDO2 gene mutant form results in increased abundance of Hydroxyindoleacetic Acid CTD PMID:32871117 NCBI chr 2:167,269,581...167,287,511
Ensembl chr 2:167,269,579...167,287,511 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19838
    role 19814
      application 19658
        food additive 16124
          food acidity regulator 11946
            acetic acid 11056
              indole-3-acetic acids 3444
                (5-hydroxyindol-3-yl)acetic acid 4
                  5-hydroxyindoleacetylglycine 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19838
    subatomic particle 19836
      composite particle 19836
        hadron 19836
          baryon 19836
            nucleon 19836
              atomic nucleus 19836
                atom 19836
                  main group element atom 19786
                    p-block element atom 19786
                      carbon group element atom 19734
                        carbon atom 19731
                          organic molecular entity 19731
                            organic molecule 19684
                              organic cyclic compound 19496
                                organic heterocyclic compound 18874
                                  organic heteropolycyclic compound 18299
                                    organic heterobicyclic compound 17233
                                      benzopyrrole 9722
                                        indoles 9411
                                          indolyl carboxylic acid 3450
                                            indol-3-yl carboxylic acid 3449
                                              indole-3-acetic acids 3444
                                                (5-hydroxyindol-3-yl)acetic acid 4
                                                  5-hydroxyindoleacetylglycine 0
paths to the root