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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:SAICAR
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Accession:CHEBI:18319 term browser browse the term
Definition:A 1-(phosphoribosyl)imidazolecarboxamide resulting from the formal condesation of the darboxy group of 5-amino-1-(5-O-phosphono-beta-D-ribofuranosyl)-1H-imidazole-4-carboxylic acid with the amino group of L-aspartic acid.
Synonyms:exact_synonym: (2S)-2-[5-amino-1-(5-O-phosphono-beta-D-ribosyl)imidazole-4-carboxamido]succinic acid;   N-{[5-amino-1-(5-O-phosphono-beta-D-ribofuranosyl)-1H-imidazol-4-yl]carbonyl}-L-aspartic acid
 related_synonym: (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinic acid;   (S)-2-[5-Amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate;   1-(5'-Phosphoribosyl)-4-(N-succinocarboxamide)-5-aminoimidazole;   1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole;   5'-Phosphoribosyl-4-(N-succinocarboxamide)-5-aminoimidazole;   Formula=C13H19N4O12P;   InChI=1S/C13H19N4O12P/c14-10-7(11(22)16-4(13(23)24)1-6(18)19)15-3-17(10)12-9(21)8(20)5(29-12)2-28-30(25,26)27/h3-5,8-9,12,20-21H,1-2,14H2,(H,16,22)(H,18,19)(H,23,24)(H2,25,26,27)/t4-,5+,8+,9+,12+/m0/s1;   InChIKey=NAQGHJTUZRHGAC-ZZZDFHIKSA-N;   SAICA riboside;   SMILES=Nc1c(ncn1[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O)C(=O)N[C@@H](CC(O)=O)C(O)=O;   Succino-AICAR;   succinyl-5-aminoimidazole-4-carboxamide-1-ribose-5-phosphate;   succinylaminoimidazolecarboxamide ribose-5'-phosphate
 alt_id: CHEBI:11028;   CHEBI:18965;   CHEBI:572;   CHEBI:78110
 xref: CAS:3031-95-6;   HMDB:HMDB0000797;   KEGG:C04823
 xref_mesh: MESH:C020635
 xref: MetaCyc:P-RIBOSYL-4-SUCCCARB-AMINOIMIDAZOLE;   PMID:23086999;   PMID:24606918;   Wikipedia:Phosphoribosylaminoimidazolesuccinocarboxamide
 cyclic_relationship: is_conjugate_acid_of CHEBI:58443


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SAICAR term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pkm pyruvate kinase M1/2 multiple interactions ISO Glucose deficiency promotes the reaction [SAICAR binds to and results in increased activity of PKM protein] CTD PMID:23086999 NCBI chr 8:60,057,629...60,079,600
Ensembl chr 8:60,057,402...60,079,599 		JBrowse link
Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 19838
    role 19814
      application 19658
        pharmaceutical 19499
          drug 19499
            anti-ulcer drug 1187
              succinic acid 652
                SAICAR 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19838
    subatomic particle 19836
      composite particle 19836
        hadron 19836
          baryon 19836
            nucleon 19836
              atomic nucleus 19836
                atom 19836
                  main group element atom 19786
                    p-block element atom 19786
                      chalcogen 19543
                        oxygen atom 19518
                          oxygen molecular entity 19518
                            hydroxides 19330
                              oxoacid 18765
                                pnictogen oxoacid 13224
                                  phosphorus oxoacid 12428
                                    phosphoric acids 11428
                                      phosphoric acid 11428
                                        phosphoric acid derivative 11237
                                          phosphate 11236
                                            organic phosphate 11236
                                              carbohydrate phosphate 1856
                                                phospho sugar 1701
                                                  aldose phosphate 1698
                                                    aldopentose phosphate 1690
                                                      ribose phosphate 1685
                                                        1-(phosphoribosyl)imidazole 109
                                                          1-(phosphoribosyl)imidazolecarboxamide 109
                                                            SAICAR 1
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