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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:toloxatone
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Accession:CHEBI:134870 term browser browse the term
Definition:A racemate consisting of equimolar amounts of (R)- and (S)-toloxatone. It is a reversible monoamine oxidase A inhibitor and antidepressant.
Synonyms:exact_synonym: rac-5-(hydroxymethyl)-3-(3-methylphenyl)-1,3-oxazolidin-2-one
 related_synonym: (5RS)-5-(hydroxymethyl)-3-(3-methylphenyl)-1,3-oxazolidin-2-one;   (RS)-toloxatone;   Delalande 69276;   Formula=C11H13NO3;   MD-69276;   MD69276;   Perenum;   humoryl;   rac-5-(hydroxymethyl)-3-(3-methylphenyl)-2-oxazolidinone;   rac-5-hydroxymethyl-3-(m-tolyl)-2-oxazolidinone;   rac-toloxatone;   racemic toloxatone;   toloxatona;   toloxatonum
 xref: CAS:29218-27-7;   DrugBank:DB09245;   Drug_Central:2702;   KEGG:D02559
 xref_mesh: MESH:C010798
 xref: PMID:10371410;   PMID:1221563;   PMID:12659549;   PMID:1352813;   PMID:1424410;   PMID:1546124;   PMID:1546145;   PMID:1705137;   PMID:1843597;   PMID:2353326;   PMID:2365178;   PMID:2768411;   PMID:29844717;   PMID:32935716;   PMID:3634492;   PMID:3810545;   PMID:409416;   PMID:41906;   PMID:494659;   PMID:551645;   PMID:6520180;   PMID:6633672;   PMID:7200786;   PMID:7884022;   PMID:8094790;   PMID:8436164;   Patent:US4699782;   Reaxys:527506;   Wikipedia:Toloxatone


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toloxatone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Maoa monoamine oxidase A decreases activity EXP toloxatone results in decreased activity of MAOA protein CTD PMID:15178694 NCBI chr  X:6,032,172...6,098,308
Ensembl chr  X:6,030,795...6,099,593 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19838
    chemical entity 19836
      chemical substance 14402
        mixture 13719
          racemate 12095
            toloxatone 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19838
    subatomic particle 19836
      composite particle 19836
        hadron 19836
          baryon 19836
            nucleon 19836
              atomic nucleus 19836
                atom 19836
                  main group element atom 19786
                    p-block element atom 19786
                      carbon group element atom 19734
                        carbon atom 19731
                          organic molecular entity 19731
                            organic molecule 19684
                              organic cyclic compound 19496
                                carbocyclic compound 18584
                                  benzenoid aromatic compound 17996
                                    benzenes 17858
                                      toluenes 7246
                                        5-(hydroxymethyl)-3-(3-methylphenyl)-1,3-oxazolidin-2-one 1
                                          (R)-toloxatone 1
                                            toloxatone 1
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