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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:roxadustat
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Accession:CHEBI:132774 term browser browse the term
Definition:An N-acylglycine resulting from the formal condensation of the amino group of glycine with the carboxy group of 4-hydroxy-1-methyl-7-phenoxyisoquinoline-3-carboxylic acid. It is an inhibitor of hypoxia inducible factor prolyl hydroxylase (HIF-PH).
Synonyms:exact_synonym: N-[(4-hydroxy-1-methyl-7-phenoxyisoquinolin-3-yl)carbonyl]glycine
 related_synonym: ASP1517;   FG 4592;   FG4592;   Formula=C19H16N2O5;   HIF prolyl-hydroxylase inhibitor;   InChI=1S/C19H16N2O5/c1-11-15-9-13(26-12-5-3-2-4-6-12)7-8-14(15)18(24)17(21-11)19(25)20-10-16(22)23/h2-9,24H,10H2,1H3,(H,20,25)(H,22,23);   InChIKey=YOZBGTLTNGAVFU-UHFFFAOYSA-N;   SMILES=O(C=1C=CC2=C(C1)C(=NC(=C2O)C(NCC(O)=O)=O)C)C=3C=CC=CC3;   roxadustatum
 xref: CAS:808118-40-3;   KEGG:D10593
 xref_mesh: MESH:C584543
 xref: PMID:26238121;   PMID:26494833;   PMID:26707978;   PMID:26808067;   PMID:26846333;   PMID:26947173;   PMID:27021233;   PMID:27082295;   PMID:27091985;   PMID:27094610;   PMID:27352308;   Reaxys:23352808


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roxadustat term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atg5 autophagy related 5 multiple interactions EXP roxadustat promotes the reaction [Hyaluronic Acid results in increased cleavage of ATG5 protein] CTD PMID:27082295 NCBI chr20:47,798,217...47,889,216
Ensembl chr20:47,798,290...47,889,209 		JBrowse link
G Bnip3 BCL2 interacting protein 3 multiple interactions EXP roxadustat promotes the reaction [Hyaluronic Acid results in increased expression of BNIP3 protein] CTD PMID:27082295 NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions
increases activity		 ISO
EXP		 [Cadmium Chloride results in increased abundance of Cadmium] inhibits the reaction [roxadustat results in increased activity of HIF1A protein]
roxadustat promotes the reaction [Hyaluronic Acid results in increased expression of HIF1A protein]		 CTD PMID:27082295 PMID:29741670 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Hk2 hexokinase 2 increases expression ISO roxadustat results in increased expression of HK2 mRNA CTD PMID:33596451 NCBI chr 4:115,234,509...115,283,530
Ensembl chr 4:115,234,509...115,283,530 		JBrowse link
G Ldha lactate dehydrogenase A increases expression ISO roxadustat results in increased expression of LDHA mRNA CTD PMID:33596451 NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions EXP roxadustat promotes the reaction [Hyaluronic Acid results in increased cleavage of MAP1LC3B protein] CTD PMID:27082295 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690 		JBrowse link
G Slc2a1 solute carrier family 2 member 1 increases expression ISO roxadustat results in increased expression of SLC2A1 mRNA CTD PMID:33596451 NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19841
    role 19817
      biological role 19815
        molecular messenger 18648
          neurotransmitter 11534
            glycine 3059
              glycine derivative 3049
                N-acylglycine 30
                  roxadustat 7
Path 2
Term Annotations click to browse term
  CHEBI ontology 19841
    subatomic particle 19839
      composite particle 19839
        hadron 19839
          baryon 19839
            nucleon 19839
              atomic nucleus 19839
                atom 19839
                  main group element atom 19789
                    main group molecular entity 19789
                      s-block molecular entity 19626
                        hydrogen molecular entity 19613
                          hydrides 19120
                            inorganic hydride 18118
                              pnictogen hydride 18107
                                nitrogen hydride 18014
                                  azane 17824
                                    ammonia 17823
                                      organic amino compound 17823
                                        amino acid 15943
                                          alpha-amino acid 13861
                                            L-alpha-amino acid 12847
                                              serine family amino acid 5538
                                                glycine 3059
                                                  glycine derivative 3049
                                                    N-acylglycine 30
                                                      roxadustat 7
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