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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:9-(tetrahydrofuryl)adenine
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Accession:CHEBI:90232 term browser browse the term
Definition:A nucleoside analogue that is adenine in which the nitrogen at position 9 has been substituted by a tetrahydrofuran-2-yl group. It is an adenylate cyclase inhibitor.
Synonyms:exact_synonym: 9-(tetrahydrofuran-2-yl)-9H-purin-6-amine
 related_synonym: 6-amino-9-(tetrahydro-2-furyl)-9H-purine;   9-(tetrahydro-2-furanyl)-9H-purin-6-amine;   9-(tetrahydro-2-furyl)-adenine;   Formula=C9H11N5O;   InChI=1S/C9H11N5O/c10-8-7-9(12-4-11-8)14(5-13-7)6-2-1-3-15-6/h4-6H,1-3H2,(H2,10,11,12);   InChIKey=UKHMZCMKHPHFOT-UHFFFAOYSA-N;   SMILES=C12=C(N=CN1C3OCCC3)C(=NC=N2)N;   SQ 22,536;   SQ-22536;   SQ22536
 xref: CAS:17318-31-9;   LINCS:LSM-1656
 xref_mesh: MESH:C017759
 xref: PMID:10193763;   PMID:11334872;   PMID:11858802;   PMID:1669444;   PMID:1711430;   PMID:26350463;   PMID:6326343;   Reaxys:534250


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9-(tetrahydrofuryl)adenine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gcg glucagon multiple interactions ISO 9-(tetrahydro-2-furyl)-adenine inhibits the reaction [geraniol results in increased secretion of GCG protein] CTD PMID:29070885 NCBI chr 3:47,113,914...47,122,958
Ensembl chr 3:47,113,914...47,122,929 		JBrowse link
G Pnpla6 patatin-like phospholipase domain containing 6 decreases expression ISO 9-(tetrahydro-2-furyl)-adenine results in decreased expression of PNPLA6 mRNA; 9-(tetrahydro-2-furyl)-adenine results in decreased expression of PNPLA6 protein CTD PMID:20380879 NCBI chr12:1,574,387...1,603,735
Ensembl chr12:1,560,363...1,603,734 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO 9-(tetrahydro-2-furyl)-adenine inhibits the reaction [methylmercuric chloride results in increased expression of PTGS2 protein] CTD PMID:28958600 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    role 19784
      biological role 19782
        inhibitor 18877
          enzyme inhibitor 18704
            EC 4.* (lyase) inhibitor 7379
              EC 4.6.* (P-O lyase) inhibitor 75
                EC 4.6.1.1 (adenylate cyclase) inhibitor 5
                  9-(tetrahydrofuryl)adenine 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
        hadron 19806
          baryon 19806
            nucleon 19806
              atomic nucleus 19806
                atom 19806
                  main group element atom 19756
                    p-block element atom 19756
                      carbon group element atom 19705
                        carbon atom 19702
                          organic molecular entity 19702
                            organic molecule 19655
                              organic cyclic compound 19468
                                organic heterocyclic compound 18848
                                  organic heteropolycyclic compound 18278
                                    organic heterobicyclic compound 17216
                                      imidazopyrimidine 7713
                                        purines 7712
                                          aminopurine 6717
                                            6-aminopurines 1025
                                              adenine 1022
                                                9-(tetrahydrofuryl)adenine 3
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