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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:remifentanil
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Accession:CHEBI:8802 term browser browse the term
Definition:A piperidinecarboxylate ester that is methyl piperidine-4-carboxylate in which the hydrogen attached to the nitrogen is substituted by a 3-methoxy-3-oxopropyl group and the hydrogen at position 4 is substituted the nitrogen of N-propanoylaniline.
Synonyms:exact_synonym: methyl 1-(3-methoxy-3-oxopropyl)-4-[phenyl(propanoyl)amino]piperidine-4-carboxylate
 related_synonym: Formula=C20H28N2O5;   InChI=1S/C20H28N2O5/c1-4-17(23)22(16-8-6-5-7-9-16)20(19(25)27-3)11-14-21(15-12-20)13-10-18(24)26-2/h5-9H,4,10-15H2,1-3H3;   InChIKey=ZTVQQQVZCWLTDF-UHFFFAOYSA-N;   SMILES=CCC(=O)N(c1ccccc1)C1(CCN(CCC(=O)OC)CC1)C(=O)OC
 alt_id: CHEBI:211871
 xref: CAS:132875-61-7;   DrugBank:DB00899;   Drug_Central:2363;   HMDB:HMDB0015036;   KEGG:C08021;   KEGG:D08473
 xref_mesh: MESH:C071741
 xref: Patent:EP383579;   Patent:US5019583;   Reaxys:4358750;   Wikipedia:Remifentanil



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remifentanil term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CASP3 caspase 3 multiple interactions ISO [Antagomirs results in decreased expression of MIR205 mRNA] promotes the reaction [Remifentanil inhibits the reaction [[Oxygen co-treated with Dithionite] results in increased expression of CASP3 protein modified form]]; [Antagomirs results in decreased expression of MIR205 mRNA] promotes the reaction [Remifentanil inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of CASP3 protein modified form]]; MIR205 mRNA inhibits the reaction [Remifentanil inhibits the reaction [[Oxygen co-treated with Dithionite] results in increased expression of CASP3 protein modified form]]; Remifentanil inhibits the reaction [[Oxygen co-treated with Dithionite] results in increased expression of CASP3 protein modified form]; Remifentanil inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of CASP3 protein modified form] CTD PMID:34078833 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062
JBrowse link
G GRIN2B glutamate ionotropic receptor NMDA type subunit 2B multiple interactions
increases phosphorylation
ISO Ketamine inhibits the reaction [remifentanil results in increased phosphorylation of GRIN2B protein] CTD PMID:20042082 NCBI chr12:13,537,337...13,982,134
Ensembl chr12:13,437,942...13,982,002
JBrowse link
G HTR3A 5-hydroxytryptamine receptor 3A affects activity EXP remifentanil affects the activity of HTR3A protein CTD PMID:18635474 NCBI chr11:113,975,108...113,990,313
Ensembl chr11:113,975,075...113,990,313
JBrowse link
G MIR205 microRNA 205 multiple interactions ISO [Antagomirs results in decreased expression of MIR205 mRNA] promotes the reaction [Remifentanil inhibits the reaction [[Oxygen co-treated with Dithionite] results in increased expression of CASP3 protein modified form]]; [Antagomirs results in decreased expression of MIR205 mRNA] promotes the reaction [Remifentanil inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in decreased expression of PINK1 protein]]; [Antagomirs results in decreased expression of MIR205 mRNA] promotes the reaction [Remifentanil inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of CASP3 protein modified form]]; [Antagomirs results in decreased expression of MIR205 mRNA] promotes the reaction [Remifentanil inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of MIR205 mRNA]]; [Antagomirs results in decreased expression of MIR205 mRNA] which results in increased susceptibility to Remifentanil; MIR205 mRNA inhibits the reaction [Remifentanil inhibits the reaction [[Oxygen co-treated with Dithionite] results in increased expression of CASP3 protein modified form]]; Remifentanil inhibits the reaction [[Oxygen co-treated with Dithionite] results in increased expression of MIR205 mRNA]; Remifentanil inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of MIR205 mRNA] CTD PMID:34078833 NCBI chr 1:209,432,133...209,432,242
Ensembl chr 1:209,432,133...209,432,242
JBrowse link
G PINK1 PTEN induced kinase 1 multiple interactions ISO [Antagomirs results in decreased expression of MIR205 mRNA] promotes the reaction [Remifentanil inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in decreased expression of PINK1 protein]]; Remifentanil inhibits the reaction [[Oxygen co-treated with Dithionite] results in decreased expression of PINK1 protein]; Remifentanil inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in decreased expression of PINK1 protein] CTD PMID:34078833 NCBI chr 1:20,633,458...20,651,511
Ensembl chr 1:20,633,458...20,651,511
JBrowse link
G PRKCG protein kinase C gamma multiple interactions
affects localization
ISO Lidocaine inhibits the reaction [remifentanil affects the localization of PRKCG protein] CTD PMID:19955894 NCBI chr19:53,881,094...53,907,652
Ensembl chr19:53,879,190...53,907,652
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26089
    role 26005
      biological role 25984
        pharmacological role 22085
          analgesic 15555
            opioid analgesic 677
              remifentanil 6
                remifentanil hydrochloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 26089
    subatomic particle 26064
      composite particle 26064
        hadron 26064
          baryon 26064
            nucleon 26016
              atomic nucleus 26064
                atom 26064
                  main group element atom 25891
                    main group molecular entity 25891
                      s-block molecular entity 25200
                        hydrogen molecular entity 24793
                          hydrides 22993
                            inorganic hydride 20521
                              pnictogen hydride 20462
                                nitrogen hydride 20240
                                  azane 19966
                                    ammonia 19945
                                      organic amino compound 19965
                                        primary amino compound 9946
                                          primary amine 6522
                                            primary arylamine 3888
                                              aniline 3687
                                                anilide 1160
                                                  remifentanil 6
                                                    remifentanil hydrochloride 0
paths to the root