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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:mycophenolate mofetil
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Accession:CHEBI:8764 term browser browse the term
Definition:A carboxylic ester resulting from the formal condensation between the carboxylic acid group of mycophenolic acid and the hydroxy group of 2-(morpholin-4-yl)ethanol. In the liver, it is metabolised to mycophenolic acid, an immunosuppressant for which it is a prodrug. It is widely used to prevent tissue rejection following organ transplants as well as for the treatment of certain autoimmune diseases.
Synonyms:exact_synonym: 2-(morpholin-4-yl)ethyl (4E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4-methylhex-4-enoate
 related_synonym: 2-morpholinoethyl (E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoate;   Cellcept;   Formula=C23H31NO7;   InChI=1S/C23H31NO7/c1-15(5-7-19(25)30-13-10-24-8-11-29-12-9-24)4-6-17-21(26)20-18(14-31-23(20)27)16(2)22(17)28-3/h4,26H,5-14H2,1-3H3/b15-4+;   InChIKey=RTGDFNSFWBGLEC-SYZQJQIISA-N;   MMF;   RS 61443;   SMILES=COc1c(C)c2COC(=O)c2c(O)c1C\\C=C(/C)CCC(=O)OCCN1CCOCC1;   mycophenolic acid morpholinoethyl ester
 xref: CAS:128794-94-5;   DrugBank:DB00688;   Drug_Central:1859;   HMDB:HMDB0014826;   KEGG:C07908;   KEGG:D00752
 xref_mesh: MESH:C063008
 xref: PMID:11099793;   PMID:11490743;   PMID:15572389;   PMID:15992049;   PMID:16979992;   PMID:19858585;   PMID:21180633;   PMID:21710356;   PMID:22081165;   PMID:22294686;   PMID:22310598;   PMID:22417996;   PMID:22460418;   PMID:22560143;   PMID:8826401;   PMID:9274835;   Reaxys:7500599;   Wikipedia:Mycophenolate_mofetil


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mycophenolate mofetil term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nphs1 NPHS1 adhesion molecule, nephrin multiple interactions EXP Mycophenolate mofetil inhibits reaction [streptozotocin decreases expression of Nphs1 mRNA and protein in kidney] RGD PMID:17624267 RGD:38596322 NCBI chr 1:85,720,812...85,749,079
Ensembl chr 1:85,720,812...85,749,078 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19844
    role 19820
      biological role 19818
        antimicrobial agent 18191
          mycophenolic acid 114
            mycophenolate mofetil 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19844
    subatomic particle 19842
      composite particle 19842
        hadron 19842
          baryon 19842
            nucleon 19809
              atomic nucleus 19842
                atom 19842
                  main group element atom 19792
                    p-block element atom 19792
                      carbon group element atom 19738
                        carbon atom 19734
                          organic molecular entity 19734
                            heteroorganic entity 19486
                              organochalcogen compound 19249
                                organooxygen compound 19167
                                  carbon oxoacid 18634
                                    carboxylic acid 18631
                                      monocarboxylic acid 18004
                                        fatty acid 16812
                                          unsaturated fatty acid 1099
                                            monounsaturated fatty acid 605
                                              hexenoic acid 114
                                                hex-4-enoic acid 114
                                                  mycophenolic acid 114
                                                    mycophenolate mofetil 1
paths to the root