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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:neohesperidin dihydrochalcone
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Accession:CHEBI:83535 term browser browse the term
Definition:A member of the dihydrochalcones that is 3,2',4',6'-tetrahydroxy-4-methoxydihydrochalcone attached to a neohesperidosyl residue at position 4' via glycosidic linkage. It is found in sweet orange.
Synonyms:exact_synonym: 3,5-dihydroxy-4-[3-(3-hydroxy-4-methoxyphenyl)propanoyl]phenyl 2-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranoside
 related_synonym: Formula=C28H36O15;   InChI=1S/C28H36O15/c1-11-21(34)23(36)25(38)27(40-11)43-26-24(37)22(35)19(10-29)42-28(26)41-13-8-16(32)20(17(33)9-13)14(30)5-3-12-4-6-18(39-2)15(31)7-12/h4,6-9,11,19,21-29,31-38H,3,5,10H2,1-2H3/t11-,19+,21-,22+,23+,24-,25+,26+,27-,28+/m0/s1;   InChIKey=ITVGXXMINPYUHD-CUVHLRMHSA-N;   SMILES=COc1ccc(CCC(=O)c2c(O)cc(O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](O)[C@H]3O)cc2O)cc1O
 xref: CAS:20702-77-6;   HMDB:HMDB0030542
 xref_mesh: MESH:C013613
 xref: PMID:23562496;   PMID:24274324;   PMID:24530446;   Patent:KR20110088743;   Patent:WO2011066754;   Reaxys:4285336;   Wikipedia:Neohesperidin_dihydrochalcone


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neohesperidin dihydrochalcone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 multiple interactions ISO neohesperidin dihydrochalcone inhibits the reaction [Carbon Tetrachloride results in increased expression of CASP3 protein] CTD PMID:24530446 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 multiple interactions ISO neohesperidin dihydrochalcone inhibits the reaction [Carbon Tetrachloride results in increased expression of CASP8 protein] CTD PMID:24530446 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Cat catalase multiple interactions ISO neohesperidin dihydrochalcone inhibits the reaction [Carbon Tetrachloride results in decreased expression of CAT protein] CTD PMID:24530446 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO neohesperidin dihydrochalcone inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein] CTD PMID:24530446 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO neohesperidin dihydrochalcone inhibits the reaction [Carbon Tetrachloride results in increased expression of IL6 protein] CTD PMID:24530446 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO neohesperidin dihydrochalcone inhibits the reaction [Carbon Tetrachloride results in increased expression of NOS2 protein] CTD PMID:24530446 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO neohesperidin dihydrochalcone inhibits the reaction [Carbon Tetrachloride results in increased expression of PTGS2 protein] CTD PMID:24530446 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Tas1r2 taste 1 receptor member 2 multiple interactions ISO lactisole inhibits the reaction [neohesperidin dihydrochalcone results in increased activity of [TAS1R3 protein binds to TAS1R2 protein]]; neohesperidin dihydrochalcone results in increased activity of [TAS1R3 protein binds to TAS1R2 protein] CTD PMID:17935609 NCBI chr 5:151,909,617...151,925,760
Ensembl chr 5:151,830,701...151,925,345 		JBrowse link
G Tas1r3 taste 1 receptor member 3 multiple interactions
affects binding		 ISO lactisole inhibits the reaction [neohesperidin dihydrochalcone results in increased activity of [TAS1R3 protein binds to TAS1R2 protein]]; neohesperidin dihydrochalcone binds to and results in increased activity of TAS1R3 protein; neohesperidin dihydrochalcone results in increased activity of [TAS1R3 protein binds to TAS1R2 protein]
neohesperidin dihydrochalcone binds to TAS1R3 protein		 CTD PMID:17935609 PMID:20173092 NCBI chr 5:166,468,703...166,472,759
Ensembl chr 5:166,469,589...166,472,742 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    role 19784
      biological role 19782
        xenobiotic 18707
          neohesperidin dihydrochalcone 9
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
        hadron 19806
          baryon 19806
            nucleon 19806
              atomic nucleus 19806
                atom 19806
                  main group element atom 19756
                    p-block element atom 19756
                      carbon group element atom 19705
                        carbon atom 19702
                          organic molecular entity 19702
                            heteroorganic entity 19460
                              organochalcogen compound 19224
                                organooxygen compound 19141
                                  carbohydrates and carbohydrate derivatives 15270
                                    carbohydrate 15270
                                      oligosaccharide 618
                                        disaccharide 524
                                          glycosylglucose 213
                                            alpha-L-rhamnopyranosyl-(1->2)-beta-D-glucopyranose 165
                                              neohesperidoside 165
                                                neohesperidin dihydrochalcone 9
paths to the root