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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:oxaprozin
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Accession:CHEBI:7822 term browser browse the term
Definition:A monocarboxylic acid that is a propionic acid derivative having a 4,5-diphenyl-1,3-oxazol-2-yl substituent at position 3. It is non-steroidal anti-inflammatory drug commonly used to relieve the pain and inflammatory responses associated with osteoarthritis and rheumatoid arthritis.
Synonyms:exact_synonym: 3-(4,5-diphenyl-1,3-oxazol-2-yl)propanoic acid
 related_synonym: Danoprox;   Daypro;   Dayrun;   Deflam;   Duraprox;   Formula=C18H15NO3;   InChI=1S/C18H15NO3/c20-16(21)12-11-15-19-17(13-7-3-1-4-8-13)18(22-15)14-9-5-2-6-10-14/h1-10H,11-12H2,(H,20,21);   InChIKey=OFPXSFXSNFPTHF-UHFFFAOYSA-N;   SMILES=OC(=O)CCc1nc(-c2ccccc2)c(o1)-c1ccccc1;   Walix;   oxaprozina;   oxaprozine;   oxaprozinum
 xref: CAS:21256-18-8;   DrugBank:DB00991;   Drug_Central:2013;   HMDB:HMDB0015126;   KEGG:C07356;   KEGG:D00463;   LINCS:LSM-2553
 xref_mesh: MESH:C008729
 xref: PMID:1603605;   PMID:1617910;   PMID:19338579;   PMID:19672323;   PMID:20206429;   PMID:23865335;   PMID:385873;   PMID:6432657;   PMID:6611288;   PMID:6863578;   PMID:9459947;   Patent:FR2001036;   Patent:GB1206403;   Patent:US3578671;   Patent:WO2007082542;   Reaxys:1083168;   Wikipedia:Oxaprozin


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oxaprozin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hsf1 heat shock transcription factor 1 increases activity ISO Oxaprozin results in increased activity of HSF1 protein CTD PMID:34170685 NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011 		JBrowse link
G Ngfr nerve growth factor receptor increases expression ISO oxaprozin results in increased expression of NGFR protein CTD PMID:17409433 NCBI chr10:80,515,287...80,533,518
Ensembl chr10:80,515,299...80,533,518 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases activity ISO oxaprozin results in increased activity of PPARG protein CTD PMID:12065695 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G RT1-Bb RT1 class II, locus Bb affects expression ISO Oxaprozin affects the expression of HLA-DQB1 mRNA CTD PMID:25811541 NCBI chr20:4,596,558...4,602,201
Ensembl chr20:4,596,559...4,607,597 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19844
    role 19820
      biological role 19818
        pharmacological role 19064
          analgesic 14743
            oxaprozin 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 19844
    subatomic particle 19842
      composite particle 19842
        hadron 19842
          baryon 19842
            nucleon 19809
              atomic nucleus 19842
                atom 19842
                  main group element atom 19792
                    p-block element atom 19792
                      carbon group element atom 19738
                        carbon atom 19734
                          organic molecular entity 19734
                            heteroorganic entity 19486
                              organochalcogen compound 19249
                                organooxygen compound 19167
                                  carbon oxoacid 18634
                                    carboxylic acid 18631
                                      monocarboxylic acid 18004
                                        fatty acid 16812
                                          saturated fatty acid 16534
                                            propionic acid 3802
                                              oxaprozin 4
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