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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:loxoprofen
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Accession:CHEBI:76172 term browser browse the term
Definition:A monocarboxylic acid that is propionic acid in which one of the hydrogens at position 2 is substituted by a 4-[(2-oxocyclopentyl)methyl]phenyl group. A prodrug that is rapidly converted into its active trans-alcohol metabolite following oral administration.
Synonyms:exact_synonym: 2-{4-[(2-oxocyclopentyl)methyl]phenyl}propanoic acid
 related_synonym: (+-)-((2-oxocyclopentyl)methyl)hydratropic acid;   Formula=C15H18O3;   InChI=1S/C15H18O3/c1-10(15(17)18)12-7-5-11(6-8-12)9-13-3-2-4-14(13)16/h5-8,10,13H,2-4,9H2,1H3,(H,17,18);   InChIKey=YMBXTVYHTMGZDW-UHFFFAOYSA-N;   SMILES=CC(C(O)=O)c1ccc(CC2CCCC2=O)cc1;   loxoprofene;   loxoprofeno;   loxoprofenum
 xref: CAS:68767-14-6;   Drug_Central:1615;   HMDB:HMDB0041920;   KEGG:D08149;   LINCS:LSM-5054
 xref_mesh: MESH:C040656
 xref: Patent:EP1767218;   Patent:WO2008020270;   Reaxys:2860055;   Wikipedia:Loxoprofen
 cyclic_relationship: is_conjugate_acid_of CHEBI:76199


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loxoprofen term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cldn1 claudin 1 increases expression ISO loxoprofen metabolite results in increased expression of CLDN1 protein; loxoprofen results in increased expression of CLDN1 mRNA; loxoprofen results in increased expression of CLDN1 protein CTD PMID:34506768 NCBI chr11:74,421,569...74,436,728
Ensembl chr11:74,421,569...74,436,724 		JBrowse link
G Cldn3 claudin 3 increases expression ISO loxoprofen metabolite results in increased expression of CLDN3 protein; loxoprofen results in increased expression of CLDN3 mRNA; loxoprofen results in increased expression of CLDN3 protein CTD PMID:34506768 NCBI chr12:21,708,538...21,710,010
Ensembl chr12:21,708,398...21,711,001 		JBrowse link
G Cldn5 claudin 5 increases expression ISO loxoprofen metabolite results in increased expression of CLDN5 protein; loxoprofen results in increased expression of CLDN5 mRNA; loxoprofen results in increased expression of CLDN5 protein CTD PMID:34506768 NCBI chr11:82,212,822...82,214,248
Ensembl chr11:82,211,475...82,214,992 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation ISO loxoprofen metabolite results in decreased phosphorylation of MAPK1 protein; loxoprofen results in decreased phosphorylation of MAPK1 protein CTD PMID:34506768 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation ISO loxoprofen metabolite results in decreased phosphorylation of MAPK3 protein; loxoprofen results in decreased phosphorylation of MAPK3 protein CTD PMID:34506768 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mpo myeloperoxidase increases activity EXP loxoprofen results in increased activity of MPO protein CTD PMID:20586851 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Muc2 mucin 2, oligomeric mucus/gel-forming multiple interactions
decreases expression		 EXP lafutidine inhibits the reaction [loxoprofen results in decreased expression of MUC2] CTD PMID:20586851 NCBI chr 1:196,799,494...196,831,740
Ensembl chr 1:196,799,517...196,831,756 		JBrowse link
G Nos2 nitric oxide synthase 2 increases expression
multiple interactions		 EXP loxoprofen results in increased expression of NOS2
lafutidine inhibits the reaction [loxoprofen results in increased expression of NOS2]		 CTD PMID:20586851 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    role 19784
      application 19627
        pro-agent 11524
          prodrug 11284
            loxoprofen 8
              (2S)-2-(4-\{[(1R,2S)-2-hydroxycyclopentyl]methyl\}phenyl)propanoic acid 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
        hadron 19806
          baryon 19806
            nucleon 19806
              atomic nucleus 19806
                atom 19806
                  main group element atom 19756
                    p-block element atom 19756
                      carbon group element atom 19705
                        carbon atom 19702
                          organic molecular entity 19702
                            heteroorganic entity 19460
                              organochalcogen compound 19224
                                organooxygen compound 19141
                                  carbon oxoacid 18612
                                    carboxylic acid 18609
                                      monocarboxylic acid 17984
                                        fatty acid 16792
                                          saturated fatty acid 16519
                                            propionic acid 3800
                                              loxoprofen 8
                                                (2S)-2-(4-\{[(1R,2S)-2-hydroxycyclopentyl]methyl\}phenyl)propanoic acid 0
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