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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:Dihydrocorynantheine
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Accession:CHEBI:70074 term browser browse the term
Definition:An alkaloid that has formula C22H28N2O3.
Synonyms:related_synonym: 18,19-Dihydrocorynantheine;   Formula=C22H28N2O3;   InChI=1S/C22H28N2O3/c1-4-14-12-24-10-9-16-15-7-5-6-8-19(15)23-21(16)20(24)11-17(14)18(13-26-2)22(25)27-3/h5-8,13-14,17,20,23H,4,9-12H2,1-3H3/b18-13+/t14-,17-,20-/m0/s1;   InChIKey=NMLUOJBSAYAYEM-XPOGPMDLSA-N;   SMILES=[H][C@@]1(C[C@]2([H])N(CCc3c2[nH]c2ccccc32)C[C@@H]1CC)C(=C/OC)\\C(=O)OC;   hirsutine;   methyl(E)-2-[(2S,3R,12bS)-3-ethyl-1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a]quinolizin-2-yl]-3-methoxyprop-2-enoate
 xref: CAS:50439-68-4;   CAS:7729-23-9;   ChemIDplus:0050439684;   KEGG:C16953;   KEGG:C16972
 xref_mesh: MESH:C038369
 xref: PMID:21070010


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Dihydrocorynantheine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ces1d carboxylesterase 1D decreases activity
multiple interactions		 ISO hirsutine results in decreased activity of CES1 protein
[hirsutine results in decreased activity of CES1 protein] which results in decreased metabolism of Oseltamivir		 CTD PMID:37716419 NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035 		JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 decreases activity ISO hirsutine results in decreased activity of CYP2D6 protein CTD PMID:31707106 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759 		JBrowse link
G Slc3a2 solute carrier family 3 member 2 multiple interactions EXP hirsutine promotes the reaction [Glutamic Acid results in increased expression of SLC3A2 mRNA] CTD PMID:25551766 NCBI chr 1:205,604,468...205,618,931
Ensembl chr 1:205,604,468...205,618,931 		JBrowse link
G Slc7a11 solute carrier family 7 member 11 multiple interactions EXP hirsutine promotes the reaction [Glutamic Acid results in increased expression of SLC7A11 mRNA] CTD PMID:25551766 NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19841
    role 19817
      biological role 19815
        biochemical role 19529
          metabolite 19515
            Dihydrocorynantheine 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 19841
    subatomic particle 19839
      composite particle 19839
        hadron 19839
          baryon 19839
            nucleon 19839
              atomic nucleus 19839
                atom 19839
                  main group element atom 19789
                    p-block element atom 19789
                      carbon group element atom 19737
                        carbon atom 19733
                          organic molecular entity 19733
                            heteroorganic entity 19492
                              organonitrogen compound 18812
                                alkaloid 7826
                                  Dihydrocorynantheine 4
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