Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:ergosta-4,6,8(14),22-tetraen-3-one
go back to main search page
Accession:CHEBI:69431 term browser browse the term
Definition:An ergostanoid that is (22E)-ergosta-4,6,8(14),22-tetraene substituted by an oxo group at position 3. It has been isolated from the mycelia of Cordyceps sinensis.
Synonyms:exact_synonym: (22E)-ergosta-4,6,8(14),22-tetraen-3-one
 related_synonym: 24-methylcholesta-4,6,8(14),22-tetraen-3-one;   Formula=C28H40O;   InChI=1S/C28H40O/c1-18(2)19(3)7-8-20(4)24-11-12-25-23-10-9-21-17-22(29)13-15-27(21,5)26(23)14-16-28(24,25)6/h7-10,17-20,24,26H,11-16H2,1-6H3/b8-7+/t19-,20+,24+,26-,27-,28+/m0/s1;   InChIKey=OIMXTYUHMBQQJM-HSVWHVBGSA-N;   SMILES=CC(C)[C@@H](C)\\C=C\\[C@@H](C)[C@H]1CCC2=C3C=CC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C
 alt_id: CHEBI:68084
 xref: CAS:19254-69-4
 xref_mesh: MESH:C015860
 xref: PMID:21043476;   PMID:21226488;   PMID:21428374;   PMID:21848266;   Reaxys:3223568


show annotations for term's descendants           Sort by:
ergosta-4,6,8(14),22-tetraen-3-one term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle multiple interactions ISO ergosta-4,6,8(14),22-tetraen-3-one inhibits the reaction [AGT protein results in increased expression of ACTA2 protein] CTD PMID:28578904 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554 		JBrowse link
G Agt angiotensinogen multiple interactions ISO ergosta-4,6,8(14),22-tetraen-3-one inhibits the reaction [AGT protein results in decreased expression of CDH1 protein]; ergosta-4,6,8(14),22-tetraen-3-one inhibits the reaction [AGT protein results in decreased expression of HMOX1 protein]; ergosta-4,6,8(14),22-tetraen-3-one inhibits the reaction [AGT protein results in decreased expression of NFE2L2 protein]; ergosta-4,6,8(14),22-tetraen-3-one inhibits the reaction [AGT protein results in decreased expression of NPHS2 protein]; ergosta-4,6,8(14),22-tetraen-3-one inhibits the reaction [AGT protein results in increased expression of ACTA2 protein]; ergosta-4,6,8(14),22-tetraen-3-one inhibits the reaction [AGT protein results in increased expression of CCL2 protein]; ergosta-4,6,8(14),22-tetraen-3-one inhibits the reaction [AGT protein results in increased expression of COL3A1 protein]; ergosta-4,6,8(14),22-tetraen-3-one inhibits the reaction [AGT protein results in increased expression of MMP7 protein]; ergosta-4,6,8(14),22-tetraen-3-one inhibits the reaction [AGT protein results in increased expression of PTGS2 protein]; ergosta-4,6,8(14),22-tetraen-3-one inhibits the reaction [AGT protein results in increased expression of SNAI1 protein]; ergosta-4,6,8(14),22-tetraen-3-one inhibits the reaction [AGT protein results in increased expression of VIM protein]
ergosta-4,6,8(14),22-tetraen-3-one inhibits the reaction [AGT protein results in decreased expression of HMOX1 protein]; ergosta-4,6,8(14),22-tetraen-3-one inhibits the reaction [AGT protein results in decreased expression of NPHS1 protein]; ergosta-4,6,8(14),22-tetraen-3-one inhibits the reaction [AGT protein results in decreased expression of PODXL protein]; ergosta-4,6,8(14),22-tetraen-3-one inhibits the reaction [AGT protein results in decreased expression of SYNPO protein]; ergosta-4,6,8(14),22-tetraen-3-one inhibits the reaction [AGT protein results in decreased expression of WT1 protein]; ergosta-4,6,8(14),22-tetraen-3-one inhibits the reaction [AGT protein results in increased expression of CCL2 protein]; ergosta-4,6,8(14),22-tetraen-3-one inhibits the reaction [AGT protein results in increased expression of MMP7 protein]; ergosta-4,6,8(14),22-tetraen-3-one inhibits the reaction [AGT protein results in increased expression of PTGS2 protein]		 CTD PMID:28578904 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO ergosta-4,6,8(14),22-tetraen-3-one inhibits the reaction [AGT protein results in increased expression of CCL2 protein] CTD PMID:28578904 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Cdh1 cadherin 1 multiple interactions ISO ergosta-4,6,8(14),22-tetraen-3-one inhibits the reaction [AGT protein results in decreased expression of CDH1 protein] CTD PMID:28578904 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775 		JBrowse link
G Col3a1 collagen type III alpha 1 chain multiple interactions ISO ergosta-4,6,8(14),22-tetraen-3-one inhibits the reaction [AGT protein results in increased expression of COL3A1 protein] CTD PMID:28578904 NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO ergosta-4,6,8(14),22-tetraen-3-one inhibits the reaction [AGT protein results in decreased expression of HMOX1 protein] CTD PMID:28578904 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Mmp7 matrix metallopeptidase 7 multiple interactions ISO ergosta-4,6,8(14),22-tetraen-3-one inhibits the reaction [AGT protein results in increased expression of MMP7 protein] CTD PMID:28578904 NCBI chr 8:4,848,186...4,855,908
Ensembl chr 8:4,848,186...4,855,902 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions ISO ergosta-4,6,8(14),22-tetraen-3-one inhibits the reaction [AGT protein results in decreased expression of NFE2L2 protein] CTD PMID:28578904 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nphs1 NPHS1 adhesion molecule, nephrin multiple interactions ISO ergosta-4,6,8(14),22-tetraen-3-one inhibits the reaction [AGT protein results in decreased expression of NPHS1 protein] CTD PMID:28578904 NCBI chr 1:85,720,812...85,749,079
Ensembl chr 1:85,720,812...85,749,078 		JBrowse link
G Nphs2 NPHS2 stomatin family member, podocin multiple interactions ISO ergosta-4,6,8(14),22-tetraen-3-one inhibits the reaction [AGT protein results in decreased expression of NPHS2 protein] CTD PMID:28578904 NCBI chr13:68,448,720...68,461,312
Ensembl chr13:68,448,926...68,461,313 		JBrowse link
G Podxl podocalyxin-like multiple interactions ISO ergosta-4,6,8(14),22-tetraen-3-one inhibits the reaction [AGT protein results in decreased expression of PODXL protein] CTD PMID:28578904 NCBI chr 4:60,135,124...60,181,829
Ensembl chr 4:60,135,109...60,181,899 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO ergosta-4,6,8(14),22-tetraen-3-one inhibits the reaction [AGT protein results in increased expression of PTGS2 protein] CTD PMID:28578904 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Snai1 snail family transcriptional repressor 1 multiple interactions ISO ergosta-4,6,8(14),22-tetraen-3-one inhibits the reaction [AGT protein results in increased expression of SNAI1 protein] CTD PMID:28578904 NCBI chr 3:156,248,479...156,252,969
Ensembl chr 3:156,248,485...156,252,969 		JBrowse link
G Synpo synaptopodin multiple interactions ISO ergosta-4,6,8(14),22-tetraen-3-one inhibits the reaction [AGT protein results in decreased expression of SYNPO protein] CTD PMID:28578904 NCBI chr18:54,048,299...54,106,388
Ensembl chr18:54,026,152...54,102,126 		JBrowse link
G Vim vimentin multiple interactions ISO ergosta-4,6,8(14),22-tetraen-3-one inhibits the reaction [AGT protein results in increased expression of VIM protein] CTD PMID:28578904 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187 		JBrowse link
G Wt1 WT1 transcription factor multiple interactions ISO ergosta-4,6,8(14),22-tetraen-3-one inhibits the reaction [AGT protein results in decreased expression of WT1 protein] CTD PMID:28578904 NCBI chr 3:91,566,540...91,613,653
Ensembl chr 3:91,567,001...91,613,643 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    chemical entity 19806
      group 19765
        organic group 18936
          3-oxo-Delta(4)-steroid group 9159
            3-oxo-Delta(4) steroid 9159
              ergosta-4,6,8(14),22-tetraen-3-one 15
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
        hadron 19806
          baryon 19806
            nucleon 19806
              atomic nucleus 19806
                atom 19806
                  main group element atom 19756
                    p-block element atom 19756
                      carbon group element atom 19705
                        carbon atom 19702
                          organic molecular entity 19702
                            heteroorganic entity 19460
                              organochalcogen compound 19224
                                organooxygen compound 19141
                                  carbonyl compound 18869
                                    ketone 17165
                                      oxo steroid 10530
                                        3-oxo steroid 9919
                                          3-oxo-Delta(4) steroid 9159
                                            ergosta-4,6,8(14),22-tetraen-3-one 15
paths to the root