Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:alpha-cyano-4-hydroxycinnamic acid
go back to main search page
Accession:CHEBI:64340 term browser browse the term
Definition:A monohydroxycinnamic acid that is 4-hydroxycinnamic acid in which the hydrogen alpha- to the carboxy group is replaced by a cyano group. It is used as a matrix in matrix-assisted laser desorption/ionization (MALDI) mass spectrometry for the analysis of peptides and oligonucleotides.
Synonyms:exact_synonym: (2E)-2-cyano-3-(4-hydroxyphenyl)prop-2-enoic acid
 related_synonym: 2-cyano-3-(4-hydroxyphenyl)acrylic acid;   CHCA;   Formula=C10H7NO3;   InChI=1S/C10H7NO3/c11-6-8(10(13)14)5-7-1-3-9(12)4-2-7/h1-5,12H,(H,13,14)/b8-5+;   InChIKey=AFVLVVWMAFSXCK-VMPITWQZSA-N;   SMILES=OC(=O)C(\\C#N)=C\\c1ccc(O)cc1;   alpha-Cyano
 xref: CAS:28166-41-8
 xref_mesh: MESH:C007175
 xref: PMID:11217742;   PMID:14715888;   PMID:15144210;   PMID:15150841;   PMID:15694775;   PMID:16401911;   PMID:19435303;   PMID:19927305;   PMID:8750232;   Reaxys:2645333;   Wikipedia:Alpha-cyano-4-hydroxycinnamic_acid


show annotations for term's descendants           Sort by:
alpha-cyano-4-hydroxycinnamic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen multiple interactions EXP alpha-cyano-4-hydroxycinnamate inhibits the reaction [Glucose results in increased expression of AGT mRNA]; alpha-cyano-4-hydroxycinnamate inhibits the reaction [Glucose results in increased expression of AGT protein] CTD PMID:12130563 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 decreases expression ISO alpha-cyano-4-hydroxycinnamate results in decreased expression of CXCR4 mRNA; alpha-cyano-4-hydroxycinnamate results in decreased expression of CXCR4 protein CTD PMID:26384349 NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883 		JBrowse link
G Fgf21 fibroblast growth factor 21 multiple interactions ISO alpha-cyano-4-hydroxycinnamate inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of FGF21 mRNA] CTD PMID:31009676 NCBI chr 1:96,083,360...96,084,911
Ensembl chr 1:96,083,441...96,090,454 		JBrowse link
G Hk2 hexokinase 2 decreases expression ISO alpha-cyano-4-hydroxycinnamate results in decreased expression of HK2 mRNA; alpha-cyano-4-hydroxycinnamate results in decreased expression of HK2 protein CTD PMID:26384349 NCBI chr 4:115,234,509...115,283,530
Ensembl chr 4:115,234,509...115,283,530 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    role 19784
      application 19627
        MALDI matrix material 1009
          alpha-cyano-4-hydroxycinnamic acid 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
        hadron 19806
          baryon 19806
            nucleon 19806
              atomic nucleus 19806
                atom 19806
                  main group element atom 19756
                    p-block element atom 19756
                      carbon group element atom 19705
                        carbon atom 19702
                          organic molecular entity 19702
                            heteroorganic entity 19460
                              organochalcogen compound 19224
                                organooxygen compound 19141
                                  carbon oxoacid 18612
                                    carboxylic acid 18609
                                      monocarboxylic acid 17984
                                        alpha,beta-unsaturated monocarboxylic acid 13437
                                          cinnamic acids 2509
                                            hydroxycinnamic acid 1363
                                              monohydroxycinnamic acid 1020
                                                alpha-cyano-4-hydroxycinnamic acid 4
paths to the root