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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:rasagiline
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Accession:CHEBI:63620 term browser browse the term
Definition:An indane that consists of 1-aminoindane bearing an N-propargyl substituent. A selective, irreversible monoamine oxidase-B inhibitor.
Synonyms:exact_synonym: (1R)-N-(prop-2-yn-1-yl)indan-1-amine
 related_synonym: (1R)-N-propargylindan-1-amine;   (R)-N-2-Propynyl-1-indanamine;   (R)-indan-1-yl-prop-2-ynyl-amine;   Formula=C12H13N;   InChI=1S/C12H13N/c1-2-9-13-12-8-7-10-5-3-4-6-11(10)12/h1,3-6,12-13H,7-9H2/t12-/m1/s1;   InChIKey=RUOKEQAAGRXIBM-GFCCVEGCSA-N;   RAS;   SMILES=C#CCN[C@@H]1CCc2ccccc12
 xref: CAS:136236-51-6;   DrugBank:DB01367;   KEGG:D08469
 xref_mesh: MESH:C031967
 xref: PMID:20577110;   PMID:21482191;   PMID:21500280;   PMID:21628600;   PMID:21671840;   PMID:21819487;   PMID:21864207;   PMID:21878836;   PMID:21895884;   PMID:21946113;   PMID:21953831;   PMID:21971006;   PMID:21971007;   PMID:22045282;   PMID:22065207;   Reaxys:9194207;   Wikipedia:Rasagiline


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rasagiline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gdnf glial cell derived neurotrophic factor multiple interactions
increases expression		 ISO Sulfasalazine inhibits the reaction [rasagiline results in increased expression of GDNF protein]
rasagiline results in increased expression of GDNF mRNA; rasagiline results in increased expression of GDNF protein		 CTD PMID:14687604 NCBI chr 2:56,894,022...56,919,935
Ensembl chr 2:56,895,010...56,917,209 		JBrowse link
G Maob monoamine oxidase B decreases activity ISO rasagiline results in decreased activity of MAOB protein CTD PMID:21923181 NCBI chr  X:5,907,327...6,010,996
Ensembl chr  X:5,907,266...6,011,003 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO rasagiline results in increased localization of and results in increased activity of RELA protein; Sulfasalazine inhibits the reaction [rasagiline results in increased localization of and results in increased activity of RELA protein] CTD PMID:14687604 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    role 19784
      application 19627
        pharmaceutical 19468
          drug 19468
            protective agent 18187
              neuroprotective agent 15684
                rasagiline 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
        hadron 19806
          baryon 19806
            nucleon 19806
              atomic nucleus 19806
                atom 19806
                  main group element atom 19756
                    main group molecular entity 19756
                      s-block molecular entity 19595
                        hydrogen molecular entity 19582
                          hydrides 19095
                            inorganic hydride 18093
                              pnictogen hydride 18082
                                nitrogen hydride 17989
                                  azane 17798
                                    ammonia 17797
                                      organic amino compound 17797
                                        secondary amino compound 6829
                                          secondary amine 1842
                                            rasagiline 3
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