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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:NMDA receptor antagonist
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Accession:CHEBI:60643 term browser browse the term
Definition:Any substance that inhibits the action of N-methyl-D-aspartate (NMDA) receptors. They tend to induce a state known as dissociative anesthesia, marked by catalepsy, amnesia, and analgesia, while side effects can include hallucinations, nightmares, and confusion. Due to their psychotomimetic effects, many NMDA receptor antagonists are used as recreational drugs.
Synonyms:related_synonym: N-methyl-D-aspartate receptor antagonist;   N-methyl-D-aspartate receptor antagonists;   NMDA receptor antagonists;   NMDAR antagonist;   NMDAR antagonists
 alt_id: CHEBI:60797


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      CHEBI ontology 19844
        role 19820
          biological role 19818
            pharmacological role 19064
              antagonist 17248
                excitatory amino acid antagonist 10738
                  NMDA receptor antagonist 9281
                    (1R,2S)-nortilidine + 0
                    (2R,3S)-PPDA + 0
                    (2S,3R)-PPDA + 0
                    (R)-ketamine 0
                    (R,R)-tramadol + 38
                    (R,R)-tramadol hydrochloride + 0
                    (S,S)-tramadol + 38
                    (S,S)-tramadol hydrochloride + 0
                    2-amino-5-phosphonopentanoic acid 1
                    7-chlorokynurenic acid 1
                    CGP 78608 0
                    CGP 78608 hydrochloride 0
                    N-[2-(4-phenoxybenzyl)benzimidazol-5-yl]methanesulfonamide 0
                    N-\{2-[(4-benzylpiperidin-1-yl)methyl]benzimidazol-5-yl\}methanesulfonamide 0
                    PPDA 0
                    Ro 25-6981 1
                    Ro 25-6981 maleate 0
                    amantadine 11
                    amantadine hydrochloride 0
                    amantadine sulfate 0
                    dextromethadone + 32
                    dextromethorphan + 51
                    dinitrogen oxide 8
                    dizocilpine 3
                    dizocilpine maleate 102
                    eliprodil 1
                    esketamine + 0
                    esketamine hydrochloride 0
                    ethanol + 8819
                    ginsenoside Rb3 0
                    isoliquiritigenin + 84
                    ketamine + 859
                    ketamine hydrochloride + 0
                    kynurenic acid + 19
                    levomethadone + 32
                    memantine 31
                    memantine hydrochloride 0
                    methadone + 32
                    midafotel 0
                    noribogaine 0
                    orphenadrine + 419
                    orphenadrine citrate 0
                    orphenadrine hydrochloride 0
                    pentamidine 34
                    phencyclidine 94
                    rolicyclidine 0
                    tenocyclidine 0
                    tramadol 38
                    tramadol hydrochloride 0
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