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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:thiosalicylic acid
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Accession:CHEBI:59124 term browser browse the term
Definition:A sulfanylbenzoic acid that is the 2-sulfanyl derivative of benzoic acid.
Synonyms:related_synonym: 2-Carboxythiophenol;   2-Mercaptobenzoic acid;   2-Sulfanylbenzoic acid;   2-Thiosalicylic acid;   Formula=C7H6O2S;   InChI=1S/C7H6O2S/c8-7(9)5-3-1-2-4-6(5)10/h1-4,10H,(H,8,9);   InChIKey=NBOMNTLFRHMDEZ-UHFFFAOYSA-N;   SMILES=OC(=O)c1ccccc1S;   Thiophenol-2-carboxylic acid;   o-Benzoic acid thiol;   o-Carboxythiophenol;   o-Mercaptobenzoesaeure;   o-Mercaptobenzoic acid;   o-Sulfhydrylbenzoic acid;   o-Thiosalicylic acid
 xref: Beilstein:508507;   CAS:147-93-3;   Drug_Central:4856;   Gmelin:3838;   KEGG:D08586
 xref_mesh: MESH:C441201
 xref: PDBeChem:JKE;   PMID:1650428;   PMID:23934301;   PMID:24369647;   PMID:24728505;   Patent:DE189200;   Patent:DE205450;   Reaxys:508507;   Wikipedia:Thiosalicylic_acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:59127


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thiosalicylic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 multiple interactions EXP [Diethylnitrosamine co-treated with thiosalicylic acid] results in increased activity of CASP3 protein CTD PMID:19427195 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 multiple interactions EXP [Diethylnitrosamine co-treated with thiosalicylic acid] results in increased activity of CASP8 protein CTD PMID:19427195 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Fas Fas cell surface death receptor multiple interactions EXP [Diethylnitrosamine co-treated with thiosalicylic acid] results in increased expression of FAS mRNA; [Diethylnitrosamine co-treated with thiosalicylic acid] results in increased expression of FAS protein CTD PMID:19427195 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Faslg Fas ligand multiple interactions EXP thiosalicylic acid inhibits the reaction [Diethylnitrosamine results in decreased expression of FASL mRNA] CTD PMID:19427195 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215 		JBrowse link
G Mt1 metallothionein 1 decreases expression ISO thiosalicylic acid results in decreased expression of MT1 mRNA CTD PMID:19386279 NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049
Ensembl chr17:10,826,032...10,827,049 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19844
    role 19820
      biological role 19818
        pharmacological role 19064
          analgesic 14743
            non-narcotic analgesic 13911
              thiosalicylic acid 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 19844
    subatomic particle 19842
      composite particle 19842
        hadron 19842
          baryon 19842
            nucleon 19809
              atomic nucleus 19842
                atom 19842
                  main group element atom 19792
                    p-block element atom 19792
                      carbon group element atom 19738
                        carbon atom 19734
                          organic molecular entity 19734
                            heteroorganic entity 19486
                              organochalcogen compound 19249
                                organooxygen compound 19167
                                  carbon oxoacid 18634
                                    carboxylic acid 18631
                                      aromatic carboxylic acid 12620
                                        benzoic acids 12597
                                          sulfanylbenzoic acid 5
                                            thiosalicylic acid 5
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