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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:5-hydroxymethylfurfural
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Accession:CHEBI:412516 term browser browse the term
Definition:A member of the class of furans that is furan which is substituted at positions 2 and 5 by formyl and hydroxymethyl substituents, respectively. Virtually absent from fresh foods, it is naturally generated in sugar-containing foods during storage, and especially by drying or cooking. It is the causative component in honey that affects the presystemic metabolism and pharmacokinetics of GZ in-vivo.
Synonyms:exact_synonym: 5-(hydroxymethyl)furan-2-carbaldehyde
 related_synonym: 2-Hydroxymethyl-5-furfural;   5-(Hydroxymethyl)-2-furancarbonal;   5-(Hydroxymethyl)-2-furancarboxaldehyde;   5-(Hydroxymethyl)-2-furfuraldehyde;   5-(Hydroxymethyl)furan-2-aldehyde;   5-(Hydroxymethyl)furfural;   5-(Hydroxymethyl)furfurole;   5-HMF;   5-Hydroxymethyl-2-formylfuran;   5-Hydroxymethyl-2-furaldehyde;   5-Hydroxymethyl-2-furancarbaldehyde;   5-Hydroxymethylfuraldehyde;   5-Hydroxymethylfuran-2-aldehyde;   5-Hydroxymethylfurfuraldehyde;   5-Oxymethylfurfurole;   Formula=C6H6O3;   HMF;   Hydroxymethylfurfural;   Hydroxymethylfurfuralaldehyde;   Hydroxymethylfurfuraldehyde;   Hydroxymethylfurfurole;   InChI=1S/C6H6O3/c7-3-5-1-2-6(4-8)9-5/h1-3,8H,4H2;   InChIKey=NOEGNKMFWQHSLB-UHFFFAOYSA-N;   SMILES=[H]C(=O)c1ccc(CO)o1
 alt_id: CHEBI:2077;   CHEBI:42598
 xref: Beilstein:110889;   CAS:67-47-0;   Gmelin:278693;   HMDB:HMDB0034355;   KEGG:C11101;   KNApSAcK:C00029547
 xref_mesh: MESH:C008046
 xref: MetaCyc:CPD-11572;   PDBeChem:FUX;   PMID:1556177;   PMID:20082406;   PMID:20420424;   PMID:21838257;   PMID:22264628;   PMID:22757699;   PMID:22957895;   PMID:23106038;   PMID:24001819;   PMID:24054253;   PMID:24054256;   PMID:24399510;   PMID:24399607;   PMID:24408726;   PMID:24444020;   PMID:24518321;   PMID:25015917;   PMID:25333920;   PMID:25858076;   PMID:25922228;   PMID:28317713;   PMID:28395827;   PMID:2917974;   PMID:6391997;   Patent:GB591858;   Patent:GB600871;   Patent:US2929823;   Patent:US2994645;   Patent:US3066150;   Patent:US3071599;   Reaxys:110889;   Wikipedia:Hydroxymethylfurfural


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5-hydroxymethylfurfural term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nphs1 NPHS1 adhesion molecule, nephrin decreases expression EXP 5-hydroxymethylfurfural co-treated with 3,4-dideoxyglucosone co-treated with Glyoxal co-treated with Methylglyoxal cotreated with 3-deoxyglucosone co-treated with Formaldehyde co-treated with acetaldehyde decreases expression of Nphs1 protein in kidneys RGD PMID:18346151 RGD:38599007 NCBI chr 1:85,720,812...85,749,079
Ensembl chr 1:85,720,812...85,749,078 		JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 affects metabolic processing
affects activity
multiple interactions
increases activity
increases metabolic processing		 ISO
EXP		 SULT1A1 protein affects the metabolism of 5-hydroxymethylfurfural
5-hydroxymethylfurfural affects the activity of SULT1A1 protein
[SULT1A1 protein co-treated with SULT1A2 protein] results in increased susceptibility to 5-hydroxymethylfurfural
SULT1A1 protein results in increased activity of 5-hydroxymethylfurfural
SULT1A1 protein results in increased metabolism of 5-hydroxymethylfurfural		 CTD PMID:22006426 PMID:22349055 PMID:22563731 PMID:25370010 NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562 		JBrowse link
Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 19808
    role 19784
      application 19627
        indicator 8765
          5-hydroxymethylfurfural 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
        hadron 19806
          baryon 19806
            nucleon 19806
              atomic nucleus 19806
                atom 19806
                  main group element atom 19756
                    p-block element atom 19756
                      carbon group element atom 19705
                        carbon atom 19702
                          organic molecular entity 19702
                            heteroorganic entity 19460
                              organochalcogen compound 19224
                                organooxygen compound 19141
                                  carbon oxoacid 18612
                                    carboxylic acid 18609
                                      carboacyl group 17677
                                        univalent carboacyl group 17677
                                          formyl group 8999
                                            aldehyde 8999
                                              arenecarbaldehyde 139
                                                5-hydroxymethylfurfural 2
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