Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:4-Hydroxybenzophenone
go back to main search page
Accession:CHEBI:34421 term browser browse the term
Definition:A benzophenone that has formula C13H10O2.
Synonyms:related_synonym: (4-Hydroxyphenyl)phenylmethanone;   Formula=C13H10O2;   InChI=1S/C13H10O2/c14-12-8-6-11(7-9-12)13(15)10-4-2-1-3-5-10/h1-9,14H;   InChIKey=NPFYZDNDJHZQKY-UHFFFAOYSA-N;   SMILES=Oc1ccc(cc1)C(=O)c1ccccc1
 xref: CAS:1137-42-4;   KEGG:C14230
 xref_mesh: MESH:C024292


show annotations for term's descendants           Sort by:
4-Hydroxybenzophenone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adm2 adrenomedullin 2 increases expression EXP 4-hydroxybenzophenone results in increased expression of ADM2 mRNA CTD PMID:35476924 NCBI chr15:89,206,923...89,208,934
Ensembl chr15:89,206,923...89,208,934 		JBrowse link
G Akr1b7 aldo-keto reductase family 1, member B7 increases expression EXP 4-hydroxybenzophenone results in increased expression of AKR1B7 mRNA CTD PMID:35476924 NCBI chr 6:34,389,297...34,400,072
Ensembl chr 6:34,389,269...34,400,077 		JBrowse link
G Ar androgen receptor affects binding ISO 4-hydroxybenzophenone binds to AR protein CTD PMID:14565775 NCBI chr  X:97,192,363...97,366,824
Ensembl chr  X:97,192,375...97,366,821 		JBrowse link
G Atf4 activating transcription factor 4 multiple interactions
increases expression		 EXP CXCL1 protein promotes the reaction [4-hydroxybenzophenone results in increased expression of ATF4 protein] CTD PMID:35476924 NCBI chr15:80,139,385...80,141,746
Ensembl chr15:80,139,385...80,141,742 		JBrowse link
G Atf6 activating transcription factor 6 multiple interactions
increases expression		 EXP CXCL1 protein promotes the reaction [4-hydroxybenzophenone results in increased expression of ATF6 protein] CTD PMID:35476924 NCBI chr 1:170,532,026...170,696,414
Ensembl chr 1:170,532,243...170,695,340 		JBrowse link
G Atp2a3 ATPase, Ca++ transporting, ubiquitous increases expression EXP 4-hydroxybenzophenone results in increased expression of ATP2A3 mRNA CTD PMID:35476924 NCBI chr11:72,851,995...72,883,869
Ensembl chr11:72,851,995...72,883,870 		JBrowse link
G Casp3 caspase 3 increases expression
multiple interactions		 EXP 4-hydroxybenzophenone results in increased expression of CASP3 protein modified form
CXCL1 protein promotes the reaction [4-hydroxybenzophenone results in increased expression of CASP3 protein modified form]		 CTD PMID:35476924 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression EXP 4-hydroxybenzophenone results in increased expression of CCL2 mRNA CTD PMID:35476924 NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279 		JBrowse link
G Cdsn corneodesmosin increases expression EXP 4-hydroxybenzophenone results in increased expression of CDSN mRNA CTD PMID:35476924 NCBI chr17:35,854,044...35,867,811
Ensembl chr17:35,863,025...35,868,077 		JBrowse link
G Cntnap3 contactin associated protein-like 3 increases expression EXP 4-hydroxybenzophenone results in increased expression of CNTNAP3 mRNA CTD PMID:35476924 NCBI chr13:64,883,994...65,051,845
Ensembl chr13:64,883,996...65,051,769 		JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 increases expression EXP 4-hydroxybenzophenone results in increased expression of CXCL10 mRNA CTD PMID:35476924 NCBI chr 5:92,494,497...92,496,748
Ensembl chr 5:92,494,497...92,496,748 		JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 increases expression
multiple interactions		 EXP 4-hydroxybenzophenone results in increased expression of CXCL1 mRNA; 4-hydroxybenzophenone results in increased expression of CXCL1 protein
CXCL1 protein promotes the reaction [4-hydroxybenzophenone results in decreased expression of MKI67 protein]; CXCL1 protein promotes the reaction [4-hydroxybenzophenone results in increased expression of ATF4 protein]; CXCL1 protein promotes the reaction [4-hydroxybenzophenone results in increased expression of ATF6 protein]; CXCL1 protein promotes the reaction [4-hydroxybenzophenone results in increased expression of CASP3 protein modified form]		 CTD PMID:35476924 NCBI chr 5:90,933,960...90,935,952
Ensembl chr 5:90,933,962...90,937,459 		JBrowse link
G Cyb5r1 cytochrome b5 reductase 1 increases expression EXP 4-hydroxybenzophenone results in increased expression of CYB5R1 mRNA CTD PMID:35476924 NCBI chr 1:134,333,519...134,339,476
Ensembl chr 1:134,333,297...134,339,478 		JBrowse link
G Esr1 estrogen receptor 1 (alpha) increases activity
affects binding
multiple interactions		 ISO 4-hydroxybenzophenone results in increased activity of ESR1 protein
4-hydroxybenzophenone binds to ESR1 protein
4-hydroxybenzophenone binds to and results in increased activity of ESR1 protein; 4-hydroxybenzophenone inhibits the reaction [Estradiol binds to ESR1 protein]		 CTD PMID:11354909 PMID:12504345 PMID:12765246 PMID:16079615 NCBI chr10:4,561,989...4,955,633
Ensembl chr10:4,561,593...4,955,614 		JBrowse link
G Esr2 estrogen receptor 2 (beta) multiple interactions ISO 4-hydroxybenzophenone binds to and results in increased activity of ESR2 protein CTD PMID:16079615 NCBI chr12:76,167,193...76,224,033
Ensembl chr12:76,167,193...76,224,033 		JBrowse link
G Fbln5 fibulin 5 increases expression EXP 4-hydroxybenzophenone results in increased expression of FBLN5 mRNA CTD PMID:35476924 NCBI chr12:101,712,820...101,785,541
Ensembl chr12:101,712,824...101,785,314 		JBrowse link
G Fibin fin bud initiation factor homolog (zebrafish) increases expression EXP 4-hydroxybenzophenone results in increased expression of FIBIN mRNA CTD PMID:35476924 NCBI chr 2:110,191,270...110,193,338
Ensembl chr 2:110,191,262...110,193,528 		JBrowse link
G Flg filaggrin affects response to substance
multiple interactions		 ISO FLG gene mutant form affects the susceptibility to 4-hydroxybenzophenone
[FLG gene mutant form affects the susceptibility to 4-hydroxybenzophenone] which results in decreased secretion of FSHB protein; [FLG gene mutant form affects the susceptibility to 4-hydroxybenzophenone] which results in increased secretion of Estradiol		 CTD PMID:30245359 NCBI chr 3:93,180,853...93,200,996
Ensembl chr 3:93,180,830...93,200,993 		JBrowse link
G Fshb follicle stimulating hormone beta multiple interactions ISO [FLG gene mutant form affects the susceptibility to 4-hydroxybenzophenone] which results in decreased secretion of FSHB protein CTD PMID:30245359 NCBI chr 2:106,886,331...106,889,996
Ensembl chr 2:106,886,485...106,890,001 		JBrowse link
G Gdf15 growth differentiation factor 15 increases expression EXP 4-hydroxybenzophenone results in increased expression of GDF15 mRNA CTD PMID:35476924 NCBI chr 8:71,082,043...71,085,106
Ensembl chr 8:71,082,043...71,085,106 		JBrowse link
G Kcnt2 potassium channel, subfamily T, member 2 increases expression EXP 4-hydroxybenzophenone results in increased expression of KCNT2 mRNA CTD PMID:35476924 NCBI chr 1:140,173,373...140,541,783
Ensembl chr 1:140,173,896...140,539,805 		JBrowse link
G Mki67 antigen identified by monoclonal antibody Ki 67 multiple interactions
decreases expression		 EXP CXCL1 protein promotes the reaction [4-hydroxybenzophenone results in decreased expression of MKI67 protein] CTD PMID:35476924 NCBI chr 7:135,291,513...135,318,286
Ensembl chr 7:135,291,513...135,318,090 		JBrowse link
G Mylk2 myosin, light polypeptide kinase 2, skeletal muscle increases expression EXP 4-hydroxybenzophenone results in increased expression of MYLK2 mRNA CTD PMID:35476924 NCBI chr 2:152,753,265...152,764,985
Ensembl chr 2:152,753,272...152,764,988 		JBrowse link
G Ostn osteocrin increases expression EXP 4-hydroxybenzophenone results in increased expression of OSTN mRNA CTD PMID:35476924 NCBI chr16:27,125,733...27,169,959
Ensembl chr16:27,126,239...27,169,962 		JBrowse link
G P2rx3 purinergic receptor P2X, ligand-gated ion channel, 3 increases expression EXP 4-hydroxybenzophenone results in increased expression of P2RX3 mRNA CTD PMID:35476924 NCBI chr 2:84,826,893...84,867,446
Ensembl chr 2:84,828,927...84,867,806 		JBrowse link
G Slc7a3 solute carrier family 7 (cationic amino acid transporter, y+ system), member 3 increases expression EXP 4-hydroxybenzophenone results in increased expression of SLC7A3 mRNA CTD PMID:35476924 NCBI chr  X:100,122,752...100,134,058
Ensembl chr  X:100,122,816...100,129,626 		JBrowse link
G Soat2 sterol O-acyltransferase 2 increases expression EXP 4-hydroxybenzophenone results in increased expression of SOAT2 mRNA CTD PMID:35476924 NCBI chr15:102,058,853...102,071,871
Ensembl chr15:102,058,961...102,071,904 		JBrowse link
G Tgm1 transglutaminase 1, K polypeptide increases expression EXP 4-hydroxybenzophenone results in increased expression of TGM1 mRNA CTD PMID:35476924 NCBI chr14:55,937,466...55,951,378
Ensembl chr14:55,937,466...55,951,383 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22182
    chemical entity 22181
      group 22077
        inorganic group 21039
          oxo group 20190
            organic oxo compound 20190
              carbonyl compound 20190
                ketone 17957
                  aromatic ketone 12602
                    benzophenones 1285
                      4-Hydroxybenzophenone 28
Path 2
Term Annotations click to browse term
  CHEBI ontology 22182
    subatomic particle 22174
      composite particle 22174
        hadron 22174
          baryon 22174
            nucleon 22174
              atomic nucleus 22174
                atom 22174
                  main group element atom 22108
                    p-block element atom 22108
                      carbon group element atom 21909
                        carbon atom 21835
                          organic molecular entity 21835
                            heteroorganic entity 21490
                              organochalcogen compound 20980
                                organooxygen compound 20821
                                  carbonyl compound 20190
                                    ketone 17957
                                      aromatic ketone 12602
                                        benzophenones 1285
                                          4-Hydroxybenzophenone 28
paths to the root