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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:bretylium
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Accession:CHEBI:3172 term browser browse the term
Definition:A quaternary ammonium cation having 2-bromobenzyl, ethyl and two methyl groups attached to the nitrogen. It blocks noradrenaline release from the peripheral sympathetic nervous system, and is used in emergency medicine, cardiology, and other specialties for the acute management of ventricular tachycardia and ventricular fibrillation.
Synonyms:exact_synonym: N-(2-bromobenzyl)-N,N-dimethylethanaminium
 related_synonym: (2-bromobenzyl)ethyldimethylaminium;   2-bromo-N-ethyl-N,N-dimethylbenzenemethanaminium;   Formula=C11H17BrN;   InChI=1S/C11H17BrN/c1-4-13(2,3)9-10-7-5-6-8-11(10)12/h5-8H,4,9H2,1-3H3/q+1;   InChIKey=AAQOQKQBGPPFNS-UHFFFAOYSA-N;   N-ethyl-N,N-dimethyl-2-bromobenzenemethanaminium;   SMILES=CC[N+](C)(C)Cc1ccccc1Br
 xref: Beilstein:4135284;   CAS:59-41-6;   DrugBank:DB01158;   Drug_Central:394;   KEGG:C06855;   LINCS:LSM-5607;   Wikipedia:Bretylium


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bretylium tosylate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Bretylium Tosylate inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19844
    chemical entity 19842
      molecular entity 19842
        ion 16715
          organic ion 9898
            organic cation 8956
              quaternary ammonium ion 5287
                bretylium 1
                  bretylium tosylate 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19844
    subatomic particle 19842
      composite particle 19842
        hadron 19842
          baryon 19842
            nucleon 19809
              atomic nucleus 19842
                atom 19842
                  main group element atom 19792
                    main group molecular entity 19792
                      s-block molecular entity 19626
                        hydrogen molecular entity 19613
                          hydrides 19115
                            inorganic hydride 18121
                              pnictogen hydride 18110
                                nitrogen hydride 18017
                                  ammonium 8317
                                    ammonium ion derivative 8291
                                      quaternary ammonium ion 5287
                                        bretylium 1
                                          bretylium tosylate 1
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