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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:naphthazarin
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Accession:CHEBI:28849 term browser browse the term
Definition:A naphthoquinone that is 1,4-naphthoquinone in which the hydrogens at positions 5 and 8 are replaced by hydroxy groups.
Synonyms:related_synonym: 5,8-Dihydroxy-1,4-naphthoquinone;   5,8-dihydroxy-1,4-naphthalenedione;   5,8-dihydroxy-1,4-naphthosemiquinone;   5,8-dihydroxynaphthoquinone;   Formula=C10H6O4;   InChI=1S/C10H6O4/c11-5-1-2-6(12)10-8(14)4-3-7(13)9(5)10/h1-4,11-12H;   InChIKey=RQNVIKXOOKXAJQ-UHFFFAOYSA-N;   SMILES=Oc1ccc(O)c2C(=O)C=CC(=O)c12;   naphthazarine;   naphthazarone
 alt_id: CHEBI:20521;   CHEBI:7474
 xref: CAS:475-38-7;   KEGG:C01938;   KNApSAcK:C00002846
 xref_mesh: MESH:C005503
 xref: PMID:11667447;   PMID:15644912;   PMID:16019186;   PMID:17432383;   PMID:18309277;   PMID:21667044;   PMID:21765926;   PMID:21904775;   PMID:22513651;   PMID:23537652;   PMID:2435285;   PMID:24587235;   Reaxys:880561;   Wikipedia:5\,8-Dihydroxy-1\,4-naphthoquinone


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naphthazarin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO naphthazarin results in increased expression of CYP1A1 mRNA CTD PMID:26558468 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Dhodh dihydroorotate dehydrogenase (quinone) decreases activity EXP
ISO		 naphthazarin results in decreased activity of DHODH protein CTD PMID:10658902 NCBI chr19:37,551,858...37,573,327
Ensembl chr19:37,558,177...37,591,654 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    role 19784
      application 19627
        pesticide 17897
          acaricide 13696
            naphthazarin 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
        hadron 19806
          baryon 19806
            nucleon 19806
              atomic nucleus 19806
                atom 19806
                  main group element atom 19756
                    p-block element atom 19756
                      carbon group element atom 19705
                        carbon atom 19702
                          organic molecular entity 19702
                            heteroorganic entity 19460
                              organochalcogen compound 19224
                                organooxygen compound 19141
                                  carbonyl compound 18869
                                    ketone 17165
                                      cyclic ketone 15685
                                        quinone 8644
                                          naphthoquinone 1475
                                            1,4-naphthoquinones 1463
                                              hydroxy-1,4-naphthoquinone 157
                                                naphthazarin 2
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