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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:Bafilomycin B1
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Accession:CHEBI:199416 term browser browse the term
Synonyms:exact_synonym: [2-hydroxy-2-[3-hydroxy-4-[(4E,6E,12E,14Z)-10-hydroxy-3,15-dimethoxy-7,9,11,13-tetramethyl-16-oxo-1-oxacyclohexadeca-4,6,12,14-tetraen-2-yl]pentan-2-yl]-5-methyl-6-propan-2-yloxan-4-yl] (E)-4-[(2-hydroxy-5-oxocyclopenten-1-yl)amino]-4-oxobut-2-enoate
 related_synonym: Formula=C44H65NO13;   InChI=1S/C44H65NO13/c1-23(2)41-28(7)35(56-37(49)18-17-36(48)45-38-31(46)15-16-32(38)47)22-44(53,58-41)30(9)40(51)29(8)42-33(54-10)14-12-13-24(3)19-26(5)39(50)27(6)20-25(4)21-34(55-11)43(52)57-42/h12-14,17-18,20-21,23,26-30,33,35,39-42,46,50-51,53H,15-16,19,22H2,1-11H3,(H,45,48)/b14-12+,18-17+,24-13+,25-20+,34-21-;   InChIKey=KFUFLYSBMNNJTF-UNPKUBMASA-N;   SMILES=O=C1OC(C(OC)C=CC=C(CC(C(C(C=C(C=C1OC)C)C)O)C)C)C(C(O)C(C2(OC(C(C)C(C2)OC(=O)/C=C/C(=O)NC3=C(O)CCC3=O)C(C)C)O)C)C
 xref_mesh: MESH:C052501


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Bafilomycin B1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions
increases expression		 ISO
EXP		 [Rotenone co-treated with bafilomycin B1] results in increased lipidation of and results in increased cleavage of MAP1LC3B protein
bafilomycin B1 results in increased expression of MAP1LC3B protein modified form
bafilomycin B1 promotes the reaction [Cisplatin results in increased expression of MAP1LC3B protein modified form]; Cisplatin promotes the reaction [bafilomycin B1 results in increased expression of MAP1LC3B protein modified form]		 CTD PMID:30673822 PMID:32738330 NCBI chr 8:122,317,177...122,325,499
Ensembl chr 8:122,317,100...122,325,499 		JBrowse link
G Sqstm1 sequestosome 1 increases expression
multiple interactions		 EXP bafilomycin B1 results in increased expression of SQSTM1 protein
bafilomycin B1 promotes the reaction [Cisplatin results in increased expression of SQSTM1 protein]; Cisplatin promotes the reaction [bafilomycin B1 results in increased expression of SQSTM1 protein]		 CTD PMID:32738330 NCBI chr11:50,090,979...50,105,303
Ensembl chr11:50,090,193...50,101,654 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22210
    chemical entity 22209
      atom 22202
        nonmetal atom 22086
          oxygen atom 21443
            oxygen molecular entity 21443
              organooxygen compound 20846
                polyketide 11629
                  macrolide 7523
                    Bafilomycin B1 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 22210
    subatomic particle 22202
      composite particle 22202
        hadron 22202
          baryon 22202
            nucleon 22202
              atomic nucleus 22202
                atom 22202
                  main group element atom 22136
                    p-block element atom 22136
                      carbon group element atom 21936
                        carbon atom 21861
                          organic molecular entity 21861
                            heteroorganic entity 21517
                              organochalcogen compound 21005
                                organooxygen compound 20846
                                  ester 18314
                                    carboxylic ester 17392
                                      lactone 13697
                                        macrocyclic lactone 7577
                                          macrolide 7523
                                            Bafilomycin B1 2
paths to the root