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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:yoda 1
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Accession:CHEBI:194079 term browser browse the term
Definition:A member of the class of thiadiazoles that is 1,3,4-thiadiazole substituted by pyrazin-2-yl and (2,6-dichlorobenzyl)sulfanediyl groups at positions 2 and 5, respectively. It is a selective activator of mechanosensitive channel piezo1.
Synonyms:exact_synonym: 2-{5-[(2,6-dichlorobenzyl)sulfanyl]-1,3,4-thiadiazol-2-yl}pyrazine
 related_synonym: 2-((2,6-dichlorobenzyl)thio)-5-(pyrazin-2-yl)-1,3,4-thiadiazole;   2-(5-{[(2,6-dichlorophenyl)methyl]sulfanyl}-1,3,4-thiadiazol-2-yl)pyrazine;   2-[5-[[(2,6-dichlorophenyl)methyl]thio]-1,3,4-thiadiazol-2-yl]pyrazine;   Formula=C13H8Cl2N4S2;   GlyT2-IN-1;   InChI=1S/C13H8Cl2N4S2/c14-9-2-1-3-10(15)8(9)7-20-13-19-18-12(21-13)11-6-16-4-5-17-11/h1-6H,7H2;   InChIKey=BQNXBSYSQXSXPT-UHFFFAOYSA-N;   SMILES=ClC1=CC=CC(Cl)=C1CSC1=NN=C(S1)C1=NC=CN=C1;   yoda1
 xref: CAS:448947-81-7
 xref_mesh: MESH:C000708435
 xref: PMID:29428723;   PMID:29498036;   PMID:29757938;   PMID:29795280;   PMID:31437459;   PMID:31582801;   PMID:31597314;   PMID:32523536;   PMID:33208899;   PMID:33549548;   PMID:33580124;   PMID:33610907;   PMID:34097801;   PMID:34360605;   PMID:35428847;   PMID:35552510;   PMID:35725398;   PMID:35858335;   PMID:35884459;   PMID:35942515;   PMID:35954193;   PMID:36120469;   PMID:36361659;   PMID:36447422;   PMID:36457052;   PMID:36457143;   Wikipedia:Yoda1


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yoda 1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Klf2 KLF transcription factor 2 affects localization ISO yoda-1 affects the localization of KLF2 protein CTD PMID:36214828 NCBI chr16:17,521,107...17,523,739
Ensembl chr16:17,514,552...17,523,944 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19844
    role 19820
      biological role 19818
        pharmacological role 19064
          agonist 18605
            piezo1 agonist 1
              yoda 1 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19844
    subatomic particle 19842
      composite particle 19842
        hadron 19842
          baryon 19842
            nucleon 19809
              atomic nucleus 19842
                atom 19842
                  main group element atom 19792
                    p-block element atom 19792
                      carbon group element atom 19738
                        carbon atom 19734
                          organic molecular entity 19734
                            organic molecule 19687
                              organic cyclic compound 19498
                                carbocyclic compound 18584
                                  benzenoid aromatic compound 18002
                                    benzenes 17867
                                      chlorobenzenes 14848
                                        dichlorobenzene 11549
                                          yoda 1 1
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