Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:N(omega),N(omega)-dimethyl-L-arginine
go back to main search page
Accession:CHEBI:17929 term browser browse the term
Definition:A L-arginine derivative having two methyl groups both attached to the primary amino moiety of the guanidino group.
Synonyms:exact_synonym: (2S)-2-amino-5-(N',N'-dimethylcarbamimidamido)pentanoic acid;   (2S)-2-amino-5-{[(dimethylamino)(imino)methyl]amino}pentanoic acid;   N(5)-(N,N-dimethylcarbamimidoyl)-L-ornithine;   N(5)-[(dimethylamino)(imino)methyl]-L-ornithine
 related_synonym: ADMA;   Formula=C8H18N4O2;   InChI=1S/C8H18N4O2/c1-12(2)8(10)11-5-3-4-6(9)7(13)14/h6H,3-5,9H2,1-2H3,(H2,10,11)(H,13,14)/t6-/m0/s1;   InChIKey=YDGMGEXADBMOMJ-LURJTMIESA-N;   N(5)-((dimethylamino)iminomethyl)-L-ornithine;   N(G),N(G)-dimethylarginine;   N(G)-dimethylarginine;   N(G1),N(G1)-dimethylarginine;   N,N-dimethylarginine;   NG,NG-Dimethyl-L-arginine;   SMILES=CN(C)C(=N)NCCC[C@H](N)C(O)=O;   asymmetric dimethylarginine;   guanidino-N,N-dimethylarginine
 alt_id: CHEBI:12680;   CHEBI:21908;   CHEBI:25683;   CHEBI:41833;   CHEBI:7432
 xref: Beilstein:2261521;   CAS:30315-93-6;   DrugBank:DB01686;   KEGG:C03626
 xref_mesh: MESH:C018524
 xref: PDBeChem:DA2
 cyclic_relationship: is_conjugate_base_of CHEBI:58326


show annotations for term's descendants           Sort by:
N(omega),N(omega)-dimethyl-L-arginine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ddah2 DDAH family member 2, ADMA-independent multiple interactions ISO [Iron-Dextran Complex results in decreased expression of DDAH2 protein] which results in increased abundance of N,N-dimethylarginine; Arginine inhibits the reaction [[Iron-Dextran Complex results in decreased expression of DDAH2 protein] which results in increased abundance of N,N-dimethylarginine]; DDAH2 promotes the reaction [tetramethylpyrazine inhibits the reaction [Iron-Dextran Complex results in increased abundance of N,N-dimethylarginine]]; tetramethylpyrazine inhibits the reaction [[Iron-Dextran Complex results in decreased expression of DDAH2 protein] which results in increased abundance of N,N-dimethylarginine] CTD PMID:32135237 NCBI chr20:3,761,460...3,764,718
Ensembl chr20:3,761,465...3,764,511 		JBrowse link
G Slco4c1 solute carrier organic anion transporter family, member 4C1 increases uptake ISO SLCO4C1 protein results in increased uptake of N,N-dimethylarginine CTD PMID:30865704 NCBI chr 9:97,177,497...97,229,161
Ensembl chr 9:97,178,861...97,229,715 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    role 19784
      application 19627
        indicator 8765
          biomarker 6574
            L-arginine 91
              L-arginine derivative 76
                N(omega),N(omega)-dimethyl-L-arginine 2
                  N(omega),N(omega)-dimethyl-L-arginine residue 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
        hadron 19806
          baryon 19806
            nucleon 19806
              atomic nucleus 19806
                atom 19806
                  main group element atom 19756
                    main group molecular entity 19756
                      s-block molecular entity 19595
                        hydrogen molecular entity 19582
                          hydrides 19095
                            inorganic hydride 18093
                              pnictogen hydride 18082
                                nitrogen hydride 17989
                                  azane 17798
                                    ammonia 17797
                                      organic amino compound 17797
                                        amino acid 15928
                                          alpha-amino acid 13848
                                            L-alpha-amino acid 12839
                                              glutamine family amino acid 10313
                                                L-arginine 91
                                                  L-arginine derivative 76
                                                    N(omega),N(omega)-dimethyl-L-arginine 2
                                                      N(omega),N(omega)-dimethyl-L-arginine residue 0
paths to the root