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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:4-Hydroxyclonidine
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Accession:CHEBI:178136 term browser browse the term
Synonyms:exact_synonym: 3,5-dichloro-4-(4,5-dihydro-1H-imidazol-2-ylamino)phenol
 related_synonym: Formula=C9H9Cl2N3O;   InChI=1S/C9H9Cl2N3O/c10-6-3-5(15)4-7(11)8(6)14-9-12-1-2-13-9/h3-4,15H,1-2H2,(H2,12,13,14);   InChIKey=NTWBRPXHGAXREI-UHFFFAOYSA-N;   SMILES=ClC1=C(NC=2NCCN2)C(Cl)=CC(O)=C1
 xref: CAS:57101-48-1;   Chemspider:83644;   HMDB:HMDB0060555
 xref_mesh: MESH:C060689


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4-Hydroxyclonidine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 multiple interactions ISO [[CYP2D6 gene polymorphism results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Clonidine] which results in decreased chemical synthesis of 4-hydroxyclonidine; [CYP2D6 protein results in increased metabolism of Clonidine] which results in increased chemical synthesis of 4-hydroxyclonidine CTD PMID:31585114 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19844
    chemical entity 19842
      molecular entity 19842
        polyatomic entity 19799
          heteroatomic molecular entity 19755
            halide 18659
              organohalogen compound 18528
                organochlorine compound 18305
                  chlorobenzenes 14848
                    dichlorobenzene 11549
                      4-Hydroxyclonidine 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19844
    subatomic particle 19842
      composite particle 19842
        hadron 19842
          baryon 19842
            nucleon 19809
              atomic nucleus 19842
                atom 19842
                  main group element atom 19792
                    p-block element atom 19792
                      carbon group element atom 19738
                        carbon group molecular entity 19738
                          organic molecular entity 19734
                            organic molecule 19687
                              organic cyclic compound 19498
                                organic aromatic compound 19366
                                  benzenoid aromatic compound 18002
                                    benzenes 17867
                                      chlorobenzenes 14848
                                        dichlorobenzene 11549
                                          4-Hydroxyclonidine 1
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