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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:4-nitrophenyl phosphate
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Accession:CHEBI:17440 term browser browse the term
Definition:An aryl phosphate resulting from the mono-esterification of phosphoric acid with 4-nitrophenol.
Synonyms:related_synonym: 4-nitrophenyl dihydrogen phosphate;   Formula=C6H6NO6P;   InChI=1S/C6H6NO6P/c8-7(9)5-1-3-6(4-2-5)13-14(10,11)12/h1-4H,(H2,10,11,12);   InChIKey=XZKIHKMTEMTJQX-UHFFFAOYSA-N;   SMILES=OP(O)(=O)Oc1ccc(cc1)[N+]([O-])=O;   nitrophenylphosphate;   p-nitrophenyl dihydrogen phosphate;   p-nitrophenyl phosphate;   phosphoric acid, mono(4-nitrophenyl) ester;   phosphoric acid, mono(p-nitrophenyl) ester
 alt_id: CHEBI:12035;   CHEBI:1915;   CHEBI:20458;   CHEBI:40049
 xref: CAS:330-13-2;   DrugBank:DB04214;   HMDB:HMDB0060272;   KEGG:C03360
 xref_mesh: MESH:C008644
 xref: MetaCyc:CPD-194;   PDBeChem:4NP;   PMID:23305417;   Reaxys:1578142;   Wikipedia:Para-Nitrophenylphosphate
 cyclic_relationship: is_conjugate_acid_of CHEBI:61146



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4-nitrophenyl phosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acp1 acid phosphatase 1 multiple interactions
increases hydrolysis
ISO Benzoic Acid analog inhibits the reaction [ACP1 protein results in increased hydrolysis of nitrophenylphosphate]; Thiazolidines analog inhibits the reaction [ACP1 protein results in increased hydrolysis of nitrophenylphosphate] CTD PMID:24287560 NCBI chr 6:47,506,380...47,522,021
Ensembl chr 6:47,506,380...47,522,021
JBrowse link
G Alpp alkaline phosphatase, placental increases chemical synthesis ISO ALPP protein results in increased chemical synthesis of nitrophenylphosphate CTD PMID:1495895 NCBI chr 9:87,765,846...87,768,606
Ensembl chr 9:87,765,860...87,768,606
JBrowse link
G Dusp23 dual specificity phosphatase 23 decreases phosphorylation
multiple interactions
ISO DUSP23 protein results in decreased phosphorylation of nitrophenylphosphate
Edetic Acid inhibits the reaction [DUSP23 protein results in decreased phosphorylation of nitrophenylphosphate]; Ethylmaleimide inhibits the reaction [DUSP23 protein results in decreased phosphorylation of nitrophenylphosphate]; Vanadates inhibits the reaction [DUSP23 protein results in decreased phosphorylation of nitrophenylphosphate]
CTD PMID:15147733 NCBI chr13:85,097,899...85,100,054
Ensembl chr13:85,097,899...85,100,093
JBrowse link
G Pgp phosphoglycolate phosphatase decreases phosphorylation ISO PGP protein results in decreased phosphorylation of nitrophenylphosphate analog CTD PMID:24338473 NCBI chr10:13,495,232...13,497,858
Ensembl chr10:13,494,291...13,497,858
JBrowse link
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 multiple interactions
increases hydrolysis
ISO Benzoic Acid analog inhibits the reaction [PTPN1 protein results in increased hydrolysis of nitrophenylphosphate]; Thiazolidines analog inhibits the reaction [PTPN1 protein results in increased hydrolysis of nitrophenylphosphate] CTD PMID:24287560 NCBI chr 3:156,638,811...156,687,503
Ensembl chr 3:156,638,769...156,687,504
JBrowse link
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 increases hydrolysis
multiple interactions
ISO PTPN2 protein results in increased hydrolysis of nitrophenylphosphate
Benzoic Acid analog inhibits the reaction [PTPN2 protein results in increased hydrolysis of nitrophenylphosphate]; Thiazolidines analog inhibits the reaction [PTPN2 protein results in increased hydrolysis of nitrophenylphosphate]
CTD PMID:24287560 NCBI chr18:61,229,012...61,294,662
Ensembl chr18:61,229,014...61,294,627
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19844
    role 19820
      biological role 19818
        biochemical role 19525
          metabolite 19512
            xenobiotic metabolite 16084
              human xenobiotic metabolite 15673
                4-nitrophenol 1317
                  4-nitrophenyl phosphate 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 19844
    subatomic particle 19842
      composite particle 19842
        hadron 19842
          baryon 19842
            nucleon 19809
              atomic nucleus 19842
                atom 19842
                  main group element atom 19792
                    p-block element atom 19792
                      chalcogen 19548
                        oxygen atom 19491
                          oxygen molecular entity 19523
                            hydroxides 19331
                              oxoacid 18762
                                pnictogen oxoacid 14895
                                  phosphorus oxoacid 14485
                                    phosphoric acids 11416
                                      phosphoric acid 13924
                                        phosphoric acid derivative 13830
                                          phosphate 13829
                                            organic phosphate 13829
                                              aryl phosphate 7617
                                                4-nitrophenyl phosphate 6
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