Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:PJ34
go back to main search page
Accession:CHEBI:167900 term browser browse the term
Definition:A member of the class of phenanthridines that is 5,6-dihydrophenanthridine substituted at positions 2 and 6 by (N,N-dimethylglycyl)amino and oxo groups, respectively. It is a potent inhibitor of poly(ADP-ribose) polymerases PARP1 and PARP2 (IC50 of 110 nM and 86 nM, respectively) and exhibits anti-cancer, cardioprotective and neuroprotective properties.
Synonyms:related_synonym: 2-(dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridin-2-yl)acetamide;   2-(dimethylaminoacetylamino)-5,6-dihydrophenanthridine-6-one;   Formula=C17H17N3O2;   InChI=1S/C17H17N3O2/c1-20(2)10-16(21)18-11-7-8-15-14(9-11)12-5-3-4-6-13(12)17(22)19-15/h3-9H,10H2,1-2H3,(H,18,21)(H,19,22);   InChIKey=UYJZZVDLGDDTCL-UHFFFAOYSA-N;   N(2),N(2)-dimethyl-N-(6-oxo-5,6-dihydrophenanthridin-2-yl)glycinamide;   N-(5,6-dihydro-6-oxo-2-phenanthridinyl)-2-(dimethylamino)acetamide;   N-(5,6-dihydro-6-oxophenanthridine-2-yl)-2-(dimethylamino)acetamide;   PJ 34;   SMILES=CN(C)CC(=O)NC1=CC2=C(NC(=O)C3=CC=CC=C23)C=C1
 alt_id: CHEBI:44653
 xref: CAS:344458-19-1;   Chemspider:4692;   DrugBank:DB08348;   LINCS:LSM-4937;   PDBeChem:P34;   PMID:11179503;   PMID:11845877;   PMID:15458385;   PMID:16107839;   PMID:17612561;   PMID:18276581;   PMID:18575783;   PMID:18695907;   PMID:19354255;   PMID:19890834;   PMID:21190076;   PMID:21623955;   PMID:22297980;   PMID:22561282;   PMID:22995423;   PMID:23011206;   PMID:23995751;   PMID:24564608;   PMID:24900770;   PMID:25286857;   PMID:25446913;   PMID:25635049;   PMID:25934569;   PMID:26497583;   PMID:27002155;   PMID:27427773;   PMID:28001384;   PMID:28791810;   PMID:29317476;   PMID:29651748;   PMID:30139380;   PMID:30665718;   PMID:30683694;   PMID:31133874;   PMID:31276434;   PMID:31679124;   PMID:31692907;   PMID:32082490;   PMID:32478624;   PMID:32575437;   PMID:32911782;   PMID:33368686;   PMID:33484702;   PMID:33770364
 cyclic_relationship: is_conjugate_base_of CHEBI:167903


show annotations for term's descendants           Sort by:
PJ34 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Itgam integrin subunit alpha M decreases expression EXP PJ34 decreases expression of Itgam mRNA and protein in ischemic brain RGD PMID:23151666 RGD:329902065 NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    role 19784
      application 19627
        anti-inflammatory agent 16580
          PJ34 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
        hadron 19806
          baryon 19806
            nucleon 19806
              atomic nucleus 19806
                atom 19806
                  main group element atom 19756
                    p-block element atom 19756
                      carbon group element atom 19705
                        carbon atom 19702
                          organic molecular entity 19702
                            heteroorganic entity 19460
                              organochalcogen compound 19224
                                organooxygen compound 19141
                                  carbon oxoacid 18612
                                    carboxylic acid 18609
                                      carboacyl group 17677
                                        univalent carboacyl group 17677
                                          carbamoyl group 17526
                                            carboxamide 17526
                                              secondary carboxamide 1219
                                                PJ34 1
paths to the root