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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:Hydroxybupropion
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Accession:CHEBI:166487 term browser browse the term
Synonyms:exact_synonym: 1-(3-chlorophenyl)-2-[(1-hydroxy-2-methylpropan-2-yl)amino]propan-1-one
 related_synonym: Formula=C13H18ClNO2;   InChI=1S/C13H18ClNO2/c1-9(15-13(2,3)8-16)12(17)10-5-4-6-11(14)7-10/h4-7,9,15-16H,8H2,1-3H3;   InChIKey=AKOAEVOSDHIVFX-UHFFFAOYSA-N;   SMILES=ClC=1C=C(C(=O)C(NC(CO)(C)C)C)C=CC1
 xref: CAS:92264-81-8;   Chemspider:433;   HMDB:HMDB0012235
 xref_mesh: MESH:C580748


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Hydroxybupropion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 increases chemical synthesis
multiple interactions		 EXP CYP2B1 protein results in increased chemical synthesis of hydroxybupropion
[CYP2B1 protein results in increased metabolism of Bupropion] which results in increased chemical synthesis of hydroxybupropion; [Dextran Sulfate results in decreased activity of CYP2B1 protein] which results in decreased chemical synthesis of hydroxybupropion		 CTD PMID:28438436 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions
increases chemical synthesis		 ISO [CYP2B6 protein results in increased hydroxylation of Bupropion] which results in increased chemical synthesis of hydroxybupropion; [CYP2B6 protein results in increased metabolism of Bupropion] which results in increased chemical synthesis of hydroxybupropion; notopterol inhibits the reaction [[CYP2B6 protein results in increased metabolism of Bupropion] which results in increased chemical synthesis of hydroxybupropion]; Paroxetine inhibits the reaction [CYP2B6 protein results in increased chemical synthesis of hydroxybupropion]; Ticrynafen inhibits the reaction [CYP2B6 protein results in increased chemical synthesis of hydroxybupropion] CTD PMID:21915887 PMID:23850985 PMID:25084468 PMID:32198085 PMID:35366062 More... NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    chemical entity 19806
      group 19765
        inorganic group 19360
          oxo group 18869
            organic oxo compound 18869
              carbonyl compound 18869
                ketone 17165
                  aromatic ketone 12447
                    Hydroxybupropion 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
        hadron 19806
          baryon 19806
            nucleon 19806
              atomic nucleus 19806
                atom 19806
                  main group element atom 19756
                    p-block element atom 19756
                      carbon group element atom 19705
                        carbon atom 19702
                          organic molecular entity 19702
                            heteroorganic entity 19460
                              organochalcogen compound 19224
                                organooxygen compound 19141
                                  carbonyl compound 18869
                                    ketone 17165
                                      aromatic ketone 12447
                                        Hydroxybupropion 2
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