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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:norverapamil
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Accession:CHEBI:132050 term browser browse the term
Definition:A racemate comprising equimolar amounts of (R)- and (S)-norverapamil. The major active metabolite of verapamil.
Synonyms:exact_synonym: rac-2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl]amino}-2-(propan-2-yl)pentanenitrile
 related_synonym: (RS)-2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl]amino}-2-(propan-2-yl)pentanenitrile;   (RS)-norverapamil;   5-((3,4-Dimethoxyphenethyl)amino)-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile;   Formula=C26H36N2O4;   alpha-(3-((2-(3,4-Dimethoxyphenyl)ethyl)amino)propyl)-3,4-dimethoxy-alpha-(1-methylethyl)benzeneacetonitrile;   desmethylverapamil;   rac-norverapamil
 xref: CAS:67018-85-3;   Chemspider:94724;   HMDB:HMDB0060540
 xref_mesh: MESH:C016904
 xref: PMID:10336579;   PMID:10613599;   PMID:10701911;   PMID:11377051;   PMID:11456122;   PMID:11777750;   PMID:11996822;   PMID:12016885;   PMID:15563760;   PMID:15918524;   PMID:16013069;   PMID:16892180;   PMID:17981422;   PMID:18193210;   PMID:18806964;   PMID:19746412;   PMID:19898809;   PMID:20166433;   PMID:20604832;   PMID:21135265;   PMID:22300394;   PMID:22677487;   PMID:23757929;   PMID:23916407;   PMID:24044638;   PMID:24532601;   PMID:25237334;   PMID:25571292;   PMID:25650380;   PMID:26265240;   PMID:26643325;   PMID:27457673;   PMID:27750166;   PMID:8554934;   PMID:9572542;   PMID:9613945;   Reaxys:5458977;   Wikipedia:Norverapamil


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norverapamil term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 decreases activity ISO norverapamil results in decreased activity of CYP3A5 protein CTD PMID:15689501 NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19844
    role 19820
      biological role 19818
        xenobiotic 18736
          norverapamil 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19844
    subatomic particle 19842
      composite particle 19842
        hadron 19842
          baryon 19842
            nucleon 19809
              atomic nucleus 19842
                atom 19842
                  main group element atom 19792
                    main group molecular entity 19792
                      s-block molecular entity 19626
                        hydrogen molecular entity 19613
                          hydrides 19115
                            inorganic hydride 18121
                              pnictogen hydride 18110
                                nitrogen hydride 18017
                                  azane 17823
                                    ammonia 17797
                                      organic amino compound 17822
                                        secondary amino compound 6837
                                          2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl]amino\}-2-(propan-2-yl)pentanenitrile 1
                                            (R)-norverapamil 1
                                              norverapamil 1
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