Human

“Human diseases and conditions are routinely studied directly in human subjects, via controlled case studies and regulated clinical trials. However, pre-clinical studies are also vitally necessary. Animal models are employed that represent “a living organism in which normative biology or behavior can be studied, or in which a spontaneous or induced pathological process can be investigated, and in which the phenomenon in one or more respects resembles the same phenomenon in humans.” Researchers need to be able to determine and utilize the most precise models for their disease of interest; that is, models that closely mimic the human phenotypic profile for, or aspects of a disease or condition. Sometimes despite promising results with preclinical treatments in one animal model, the same treatments do not always translate to successful human clinical trials. Thus, increasingly researchers want information about more than one model organism, and research benefits greatly from being able to explore integrated data. Having both human and model organism data accessible in one place will help researchers find the data they need for both clinical and translational research. Whether a researcher is looking for models of a disease, or human variations, or is working with a particular species and is looking for corroboration in other species, the power of combined data can be applied to research within the Rat Genome Database using the tools found on this page.”

Sources: PMID:10845564; PMID:31552413; PMID:3155241; NLM Unique ID:101117739; Hau J. (2008) Sourcebook of Models for Biomedical Research; Simmons, D. (2008) Nature Education 1(1):70

Gene Ontology Annotations