Rat Strain Models

Developmental Disease Portal – Rat Strain Models

The following tables list strains which have been annotated to five categories of Developmental Diseases. For mutant strains, the mutated gene is listed after the strain symbol.

Bone Diseases, Developmental
Disease	Strain	Affected Gene
Dwarfism and Pituitary Dwarfism	SDR/Slc
Dwarfism and Pituitary Dwarfism	WIC-Tg^rdw/Kts	Tg
Gigantism	WIC-Tg(Wap-GH1)1Mni	Human GH1 transgene
Osteopetrosis	LEW-tl.BN-(D2Arb16-D2Wox8)

Congenital Abnormalities
Disease	Strain	Affected Gene
Adrenal Hyperplasia, Congenital	SDT.ZDF-Lepr^fa/Jtt	Lepr
Aganglionosis, Total Intestinal (resistance)	F344.AR-Ednrb^sl/Hkv	Ednrb
Aganglionosis, Total Intestinal (resistance)	LE/Hkv.AR-Ednrb^sl	Ednrb
Aganglionosis, Total Intestinal (susceptibility)	AR-Ednrb^sl/Hkv	Ednrb
Amelogenesis Imperfecta	WT/Jtt
Anophthalmos	MSUBL
Ataxia Telangiectasia	F344-Atm^em1Kyo	Atm
Cardiovascular Abnormalities	SHRSP
Clubfoot	WCF
Cryptorchidism	LE/Orl
Cryptorchidism	SDLEF7/Barth
Cryptorchidism	KH
Dentinogenesis Imperfecta	WT/Jtt
Hirschsprung Disease	Sl
Hirschsprung Disease (resistance)	F344.AR-Ednrb^sl/Hkv	Ednrb
Hirschsprung Disease (resistance)	LE/Hkv.AR-Ednrb^sl	Ednrb
Hirschsprung Disease (susceptibility)	AR-Ednrb^sl/Hkv	Ednrb
Hirschsprung Disease	AR-Ednrb^sl/Okkm	Ednrb
Hirschsprung Disease	LE.AR-Ednrb^sl/Okkm	Ednrb
Hydrophthalmos	UPL/Ncc
Microcephaly	WI-Cit^fhJjlo/Rrrc	Cit
Microphthalmia, Cataracts, and Iris Abnormalities	SHR-Gja8^m1Cub	Gja8
Microphthalmos	MSUBL
Microphthalmos	SD-Pax6^Sey/Mce	Pax6
Microphthalmos	UPL/Ncc
Polydactyly	SD-Brca2^m1Uwm	Brca2
Polydactyly	SHR.PD-(D8Rat42-D8Arb23)/Cub

Inborn Genetic Diseases
Disease	Strain	Affected Gene
Adenomatous Polyposis Coli	F344-Apc^PircUwm	Apc
Adrenal Hyperplasia, Congenital	SDT.ZDF-Lepr^fa/Jtt	Lepr
Albinism	DA-Tyr^em1Kyo	Tyr
Ataxia Telangiectasia	F344-Atm^em1Kyo	Atm
Canavan Disease	TRM/Kyo
Canavan Disease	W-Aspa^tmKyo	Aspa
Cystic Fibrosis	SDT/CrljJcl
Dwarfism and Pituitary Dwarfism	SDR/Slc
Dwarfism and Pituitary Dwarfism	WIC-Tg^rdw/Kts	Tg
Hepatolenticular Degeneration	LEC/Hok
Hermanski-Pudlak Syndrome	FH
Hermanski-Pudlak Syndrome	TM/Kyo
Hyperlipoproteinemia Type IV	HTG
Menkes Kinky Hair Syndrome	ACI/N
Mucopolysaccharidosis VI	MPR/Iar
Multiple Endocrine Neoplasia	SD-Cdkn1b^we	Cdkn1b
Muscular Dystrophy, Duchenne	SD-Dmd^em1Ang	Dmd
Muscular Dystrophy, Duchenne	W-Dmd^em1Kykn	Dmd
Osteopetrosis	LEW-tl.BN-(D2Arb16-D2Wox8)
X-Linked Combined Immunodeficiency Diseases	F344-Il2rg^em1Kyo	Il2rg
X-Linked Combined Immunodeficiency Diseases	F344-Il2rg^em2Kyo	Il2rg

Diseases of Newborn Infants
Disease	Strain	Affected Gene
Cystic Fibrosis	SDT/CrljJcl
Hydrophthalmos	UPL/Ncc
Kernicterus	ACI/N-j
X-Linked Combined Immunodeficiency Diseases	F344-Il2rg^em1Kyo	Il2rg
X-Linked Combined Immunodeficiency Diseases	F344-Il2rg^em2Kyo	Il2rg

Neurodevelopmental Disorders
Disease	Strain	Affected Gene
Attention Deficit Disorder with Hyperactivity	Wig/Ymas
Attention Deficit Disorder with Hyperactivity	SHR/N
Attention Deficit Disorder with Hyperactivity	SHR/NCrl
Learning Disorders	SS.SR-(D17Rat24-rs106534785)/Opaz
Learning Disorders	SS.SR-(rs105019230-D17Rat44)/Opaz
Menkes Kinky Hair Syndrome	ACI/N

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.

Functional Annotation unavailable	Annotation Distribution unavailable	Genomic Variants unavailble for Mouse Genomic Variants unavailable
Functional Annotation	Annotation Distribution	Genomic Variants

Protein-Protein Interactions unavailable	Genome Viewer unavailable	Damaging Variants unavailble for Mouse Damaging Variants unavailable
Protein-Protein Interactions	Genome Viewer	Damaging Variants

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Annotation Comparison	OLGA	Excel (Download)

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Developmental Disease Portal – Rat Strain Models

Bone Diseases, Developmental

Congenital Abnormalities

Inborn Genetic Diseases

Diseases of Newborn Infants

Neurodevelopmental Disorders