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PhysGen Knockouts

The PhysGen Knockout program (“Mechanistic Characterization of Genes for Hypertension and Renal Disease”) aimed to knock out a large number of genes nominated by genome wide association studies, combine these gene knockouts (KO) with hypertensive and normotensive strains, and phenotypically characterize them.

The scientific community was asked to nominate genes involved in the development of hypertension and renal disease. If interested in obtaining any of these strains, please contact Mindy Dwinell, Ph.D. (

The National Heart, Lung, and Blood Institute (NHLBI) has awarded Howard Jacob, PhD and the Medical College of Wisconsin an R24 Resource grant to make ~200 genetically modified rat strains over the next five years. Click here for more information.


This project was funded by the National Heart, Lung and Blood Institute of the NIH (5RC2HL101681-02).



RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.