p53 targets

Several p53 target genes are listed that include the negative E3 ubiquitin ligase regulators and genes involved in cell cycle arrest, senescence, autophagy and apoptosis. For more detailed information check the reference PMID 18431400 and accompanying Supplemental Tables 1 and 2. The genes are listed with aliases in parentheses, full names and links to gene report pages:

Mdm2 – MDM2 proto-oncogene – in diagram
Rchy1 (Pirh2, Chimp, Arnip, hARNIP) – ring finger and CHY zinc finger domain containing 1
COP1  (RFWD2, RNF200) – COP1, E3 ubiquitin ligase [human gene – the rat gene may not have enzymatic activity]
Cdkn1a (p21) – cyclin-dependent kinase inhibitor 1A
Bbc3 (Puma) – Bcl-2 binding component 3
Pmaip1 (Noxa, Apr) – phorbol-12-myristate-13-acetate-induced protein 1
Bax (Bcl2-associated X protein) – Bcl2-associated X, apoptosis regulator
Dram (damage-regulated autophagy modulator) – DNA-damage regulated autophagy modulator 1
Gadd45a (Gadd45, Ddit1) – growth arrest and DNA-damage-inducible, alpha
Serpine1 (Pai-1, PAI1A, Pai1aa, Planh) – serpin family E member 1
Tigar (LOC502894, C12orf5) – TP53 induced glycolysis regulatory phosphatase
SCO2 – SCO2, cytochrome c oxidase assembly protein [human gene – rat has only one gene – Sco1]

p53 Response Elements (RE)

The p53 response elements (RE) are represented by two pairs of head-to-head pentamers with the sequence:

RRRCWWGYYY – spacer – RRRCWWGYYY

– where R is a purine, Y is pyrimidine and W is either A or T.
However, the range of functional p53 binding sites include sequences with one or more base pairs that do not match the consensus.