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lanosterol to cholesterol enzymes

The conversion of lanosterol to cholesterol in the cholesterol biosynthetic pathway requires several reaction and enzyme types in some 19 reaction steps. The identity of the reactions has been elucidated some time ago. However, the identity of the genes encoding the human enzymes has rather recently been determined based on the identification of the molecular basis of several inherited disorders along with sequence similarity. The precise contribution of some of the candidate genes as well as the exact sequence of events is still to be established. Current models postulate the presence of two alternative routes going from lanosterol to cholesterol. See the references with PMIDs 16876788, 12668600, 12121345 and 11969204. The genes are listed with aliases in parentheses, full names and links to gene report pages:

 

Dhcr24 – 24-dehydrocholesterol reductase
Cyp51 (Ldm, P450-14DM, lanosterol 14 alpha-demethylase) – cytochrome P450, family 51
Lbr (Nbp60, Lmn2r) – lamin B receptor
Nsdhl – NAD(P) dependent steroid dehydrogenase-like
Ebp (CPXD, CDPX2) – EBP, cholesterol delta-isomerase
Sc5dl (Sc5d) – sterol-C5-desaturase
Dhcr7 (SLOS) – 7-dehydrocholesterol reductase


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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.