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Disease Portals

1. RGD has numerous disease portals, where relationships between diseases and genes, QTLs and strains can be explored in all RGD species. The landing page for all the Disease Portals is accessed by clicking “Diseases” in the top black banner of the home page or the central “Disease Portals” panel.

Jump to information about the:

Disease Portals Landing Page

Ontology, Species and Term Selection

GViewer

Term Enrichment, Analysis Tools, Model Strains, Information Links

 

Disease Portals Landing Page

The Disease Portal entry page lists all of the Disease Portals, with clickable icons and titles.

2. This Help page can be accessed using the “Click Here” link.

3. Access each of the Disease Portals by clicking the corresponding icon or title.

4. Tab-delimited text files of disease annotations can be downloaded from the download site.

 

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Ontology, Species and Term Selection

 

5. For each portal, the default view is of the disease section of the portal. Any one of nine ontologies can be selected.

6. Any one of RGD’s species can be chosen by clicking on the image. Here rat is selected.

7. For that species, the numbers of genes, QTLs and strains annotated to the selected term in the designated ontology are displayed.

8. The RGD ontology browser is presented, loaded with the selected ontology, where one can navigate to and pick a desired term. Changing the selected term changes the counts displayed (7) for the new term.

9. Downloadable gene, QTL and strain lists annotated to the chosen term are displayed.

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GViewer

10. Where available, a GViewer instance of the designated species’ chromosome complement is shown, indicating where on the chromosomes the retrieved genes (brown), QTLs (blue) and strains (green) map.

11. Clicking on a colored object brings up a horizontal close-up display window of that object in the context of other genomic features. One can also just click on the chromosome to bring up this view. This window can be dragged along the chromosome, vertically in the upper genome display, or horizontally with the scroll bar in the lower close-up display. Clicking on an object in this display links to that object’s report page.

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Term Enrichment, Analysis Tools, Model Strains, Information Links

12. An instance of MOET (Multi-Ontology Enrichment Tool) is provided to display gene enrichment results for gene annotations to any of the three branches of GO or four other ontologies. Also see the stand-alone MOET.

13. Links to a set of analysis tools from RGD and elsewhere.

14. A tool to find annotated pertinent rat strain models.

15. Links to relevant RGD pathway data, as well as links to pertinent information sources outside RGD.

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.