Genes for Rat QTL

This page lists the genes for rat disease phenotypes that have been identified by positional cloning since 1999. The table below was compiled from the published literature. Every effort is made to keep this complete as new genes are identified, however, checking PubMed would also be worthwhile.

 

Genes for rat disease phenotypes identified by positional cloning from 1999
Gene Phenotype Suceptible Strain Date Complementation Human Trait Reference
Cd36 Insulin resistance, hyperlipidaemia SHR 1999,2001 Yes Dyslipidaemia, insulin resistance, hypertension

Aitman, etal. Nat. Genet. 1999 21:76-83

Pravenec etal. Nat. Genet. 2001 27:156-8

Mertk Retinal dystrophy RCS  2000, 2001    

D’Cruz etal. Hum. Mol. Genet. 2000 9:645-51

Vollrath etal. PNAS 2001 98:12584-89 

Atrn Hypomyelination, mahogany coat color ZI  2001     Kuramoto etal. PNAS 2001 98:559-64
Ncf1  Pristane induced arthritis DA  2002     Olofsson etal. Nat. Genet. 2003 33:25-32 
Cblb Type 1 diabetes KDP  2002     Yokoi etal. Nat. Genet. 2002 31:391-4
Gimap5 (Ian4)
Type 1 diabetes BB  2002    

Hornum etal. Diabetes 2002 51:1972-9

MacMurray etal. Genome Res. 2002 12:1029-39 

PKHD1 Polycystic kidney disease sd Pck-/-  2002    Polycystic kidney disease Ward etal. Nat. Genet. 2002 30:259-69
Rab38 Platelet storage pool disease, Renal Failure FH, LE, FHH  2004,2005      
C2ta (Mhc2ta) MHC expression DA  2005    Rheumatoid arthritis, multiple sclerosis, myocardial infarction Swanberg etal. Nat. Genet. 2005 37:486-94
Fcgr3 Crescentic glomerulonephritis WKY  2006    SLE, systemic autoimmunity Rangel-Filho etal. J. Am. Soc. Nephrol. 2005 16:852-6
Fbxo10, Frmpd1 Breast cancer WF  2007    Breast cancer Oiso etal. Mamm. Genome 2004 15:307
Srebf1 Hepatic steatosis SHR  2008     Pravenec et al. Hypertension 2008 51:148-53

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