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Welcome to the MCW Gene Editing Rat Resource Center!

The National Heart, Lung, and Blood Institute (NHLBI) has awarded Melinda Dwinell, PhD and Aron Geurts, PhD at the Medical College of Wisconsin an R24 Resource grant to make ~200 genetically modified rat strains over a five year period (R24 HL114474). These models will be of interest and value to the mission of the NHLBI. The NHLBI promotes the prevention and treatment of heart, lung, and blood diseases through scientific discovery directed toward the causes of disease and translation of basic discoveries into clinical practice.

The rat strains will be made using several different gene editing technologies, making it feasible to genetically modify genes in rats in any desired background much faster than traditional technology.

Models from past rounds are available:  View Existing Models

Round 7 projects are now included in the prioritized project list.   

Application information can be found below. 

Click here to Download application instructions 

Download the application [PDF]  [MS Word]

An example of a filled application can be found [here].  

Questions: Please contact mcwcustomrats@mcw.edu

 

We are pleased to announce the results from Round 1 – 7 applications. 

The External Advisory Board reviewed all applications and prioritized the following genes for Round 1-7 modifications in associated strain (table below). Nominated genes not selected will receive feedback and can modify the application for the next round of applications. 

Gene Strain
Adora1 SS/Mcwi
Muc1 FHH/EurMcwi
Helz2 FHH-BN3/Mcwi
Mmp9 SS/Mcwi
Sh2b3 SS/Mcwi
Abcd1 DA
P2rx1 SS/Mcwi
Stk39 SS/Mcwi
Sirt3 SS/Mcwi and T2DN
Mb WKY
Egln1 WKY
Mrpl28 LEW
Rorc LEW
Scnn1g SS-BN13/Mcwi
Trpv4 WKY
Arhgef11 SS/Mcwi
Trpv2 WKY
Tert WKY
Kcnj10 SS/Mcwi
Grk4 WKY
P2rx7 PCK
Adora2a SS/Mcwi
Asic3 WKY
Gla DA
RGD1562963 LH-17LN
Pkd1 LEW
Pappa2 SS/Mcwi
Casr SS/Mcwi
Fgf13 WKY
Nfatc1 SS/Mcwi
Sik2 WKY
Arhgdia SS/Mcwi
Chrna5 LEW
Chrna3 LEW
Chrnb4 LEW
Kcnq1 SS/Mcwi
Trpc6 SS/Mcwi
Arhgef7 SS/Mcwi
Spp1 SHRSP
Avpr1b WKY
Hbegf SS-BN13/Mcwi
P2ry2 SS/Mcwi
Igh6 LEW
Vnn1 SS/HsdMcwiCrl
Myh6 WKY
Apol1 SS/Mcwi
Pr65a SS/Mcwi
Syn1 WKY/Ncrl
vGat LEW
Umod-Flox SHRSP
CAG-CreERT2 SHRSP
Prdm1-GFP LEW
Trpc3 SS/Mcwi
Podocin-GCaMP6 SS/Mcwi
Renin-Flox SS/Mcwi
Cyp11b2-CreERT2 SS/Mcwi
Mylip-Flox SS/Mcwi
Rfwd2 SS/Mcwi
VE-Cadherin-Cre SD
Ereg-loxP-GFP-loxP-tdTomato SD
Axl SS/Mcwi
Pon1 SS/Mcwi
Pon3 SS/Mcwi
Cx3cr1-tdTomato WKY/NCrl
low affinity cAMP SD
high affinity cAMP SD
CAG-Pde3a SS/Mcwi
CAG-Pde3a-T455N

SS/Mcwi
Avpr2 SS/Mcwi
CAG-Wisp2 SS/Mcwi
Cd14 SS/Mcwi
Kcnj13 SS/Mcwi
Nlrp10 SS/Mcwi
Nlrp3 SS/Mcwi
CAG-CreERT2 WKY
Trpc6 T2DN
Vwf SS/Mcwi
F8 LEW
Vwf LEW
Arhgef7 SS/Mcwi
Cd55 SD
Eln SHR
F8 LEW
Slc16a1 WKY
Nlrp12 SS/Mcwi
Nox4 T2DN
P2ry2 SS/Mcwi
Prl1 SS/Mcwi
Ptgs2 SS/Mcwi
Thbs1 SS/Mcwi
Tph1 WKY
Nkx2-5 Lewi
EGFP-L10a SS/Mcwi
Gja5 WKY
P2rx7 SS/Mcwi
Cryab SS/Mcwi
Cgnl1 SS/Mcwi
Resp18 SS/Mcwi
F2r T2DN
Tph1 DA
Dll4 Wag/RijCmcr
Mep1a SD
Drp1 SD
Mrf1 SD
Ptk2b SS
Nppa SS/Mcwi
Sry (Trangenic and KO) SS/Mcwi
Mybphl FHH
Tert SD
Klrb1a SHR
Kcnj2 SS/Mcwi
Tlr4 SS/Mcwi
Per1 SS/Mcwi
Pcsk6 SS/Mcwi
Glp1r LEW
Hcrt SHR
Xdh SS/Mcwi

 

    


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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.