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Solberg Woods, Leah, Ph.D.

Assistant Professor, Pediatrics
Medical College of Wisconsin,
8701 Watertown Plank Road,
Milwaukee, WI 53226.

Website

Research Interests:
– genetics of type 2 diabetes
– metabolic disorders related to diabetes

Research in my laboratory involves the use of heterogeneous stock rats to fine-map several complex traits.  We are particularly interested in traits involved in type 2 diabetes and related metabolic disorders.  Heterogeneous stock rats originate from eight inbred strains, which are then bred together for many generations in an effort to minimize inbreeding. After many generations of breeding, the distance between recombinants is greatly reduced, thus enabling fine-mapping of loci to regions of less than five Megabases.  We have recently fine-mapped a glucose tolerance locus on rat chromosome 1 to only 2.4 Mb.  Current work in my laboratory involves using both sequencing and expression analysis to identify the causative gene or variant in this region.  In addition, we have recently received funding to map multiple metabolic traits across the entire rat genome.  We are also interested in comorbidites associated with type 2 diabetes and have been funded to map traits associated with kidney injury and to determine if HS rats will be useful as a resource for fine-mapping loci for diabetic nephropathy.


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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.