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Cancer Portal – Related Links

Databases and Websites:

RGD Interactive Pathway Suite Network Diagrams

  Gene Expression and Regulation Pathway Suite Network Network includes:

Transcription and Transcription-Coupled Events Pathway Suite Suite includes:
RNA polymerase I transcription pathway
RNA polymerase II transcription pathway
RNA polymerase III transcription pathway
Spliceosomal pathway

Epigenetic Regulation/Control – Chromatin Modification/Remodeling
    Pathway Suite Suite includes:
Chromatin remodeling pathway
DNA modification pathway
Histone modification pathway

  Glucose Homeostasis Pathway Suite Network Network includes:

Pathway Suite for the Metabolism of Glucose and Related Molecules Pathways
Suite includes:
Glycolysis pathway
Pyruvate metabolic pathway
Pentose phosphate pathway
Hexosamine biosynthetic pathway
Glycogen biosynthetic pathway
Gluconeogenesis pathway
Glycogen degradation pathway

  S-adenosylmethionine Homeostasis Pathway Suite Network Network includes:

SAM-homeostasis-related Metabolic Pathway Suite Suite includes:
Methionine cycle/metabolic pathway
Homocysteine metabolic pathway
Folate cycle metabolic pathway
Polyamine metabolic pathway

RGD Interactive Pathway Suite Diagrams

  Calcium Homeostasis Pathway Suite Suite includes:
Calcium transport pathway
Calcium/calcium-mediated signaling pathway
Calcium signaling pathway via the calcium-sensing receptor
Parathyroid hormone signaling pathway
Calcium/calmodulin dependent kinase 2 signaling pathway

Doxorubicin Pathway Suite Suite includes:
Doxorubicin drug pathway
Doxorubicin response pathway
Doxorubicin pharmacodynamics pathway
Doxorubicin pharmacokinetics pathway

Prostate Cancer Pathway Suite Suite includes:
Steroid hormone biosynthetic pathway
Testosterone biosynthetic pathway
Androgen signaling pathway
Altered androgen signaling pathway
Altered p53 signaling pathway
Prostate cancer pathway

RNA Maturation, Transport and Surveillance (QC) and Protein Translation Pathway Suite Suite includes:
Spliceosomal pathway
mRNA nuclear export pathway
Ribosome biogenesis pathway
Translation pathway

Pathway Suite for the Glucose Homeostasis-related Regulatory and Signaling Pathways Suite includes:
Insulin Secretion Pathway
Insulin Responsive Facilitated Sugar Transporter Mediated Glucose Transport Pathway
Insulin Signaling Pathway
Glucagon Signaling Pathway

SAM-homeostasis-related Regulatory Pathway Suite Suite includes:
DNA modification pathway
Histone modification pathway

DNA Damage Response Pathway Suite Suite includes:
Mismatch repair pathway
Nucleotide excision repair pathway
Non-homologous end joining pathway of double-strand break repair
Homologous recombination pathway of double-strand break repair
Ataxia telangiectasia-mutated (ATM) signaling pathway
p53 signaling pathway
Intrinsic apoptotic pathway

Estrogen Pathway Suite
 Suite includes:
Estradiol biosynthetic pathway
Estrogen signaling pathway
Anti-estrogen drug pathway
Cholesterol biosyntheic pathway
Sterol regulatory element-binding protein signaling pathway
Bisphenol A response pathway

RGD Interactive Pathway Diagrams
axitinib drug pathway
colorectal cancer pathway
endometrial cancer pathway
gefitinib drug pathway
non-small cell lung cancer pathway
pancreatic cancer pathway
renal cell cancer pathway

RGD Phenotypes and Models:  Mammary Cancer

The Genetics of Breast Cancer

U.S. National Library of Medicine Genetics Home Reference
Health Conditions A-Z
       Cancers A-Z

National Cancer Institute
NCI Data Catalog
NCI Cancer Genomics
NCI Cancer Biology
NCI Bioinformatics and Cancer

The Cancer Genome Atlas

The Tumor Gene Family of Databases

Centers for Disease Control and Prevention –  Cancer Prevention and Control

The Danish Centre for Translational Breast Cancer Research

OMIM Home Page
OMIM – Breast Cancer
OMIM – Prostate Cancer
OMIM – Renal Cell Carcinoma
OMIM – Bladder Cancer
OMIM – Testicular Tumors
OMIM – Cervical Cancer
OMIM – Ovarian Cancer, Epithelial

GeneCards Home Page

The Human Gene Mutation Database

NCBI – Genes and Disease Home Page
Genes and Disease – Cancers
Genes and Disease – Breast and Ovarian Cancer
Genes and Disease – Prostate Cancer
          Genes and Disease – Polycystic Kidney Disease
          Genes and Disease – Small Cell Lung Carcinoma

Genetic Association Database Home Page Please note that the Genetic Association Database has been retired. This link will take you to a page with options to download the data from August 2014.

Mouse Tumor Biology

The Immunology Link Cancer Information Page

(Please note that this list is intended to suggest locations for more information and is not intended to be exhaustive.  However, if you believe your website or database should be included in this list, please contact us to let us know about your resource.)

Links to Cancer-related Videos:

Pathways to Cancer
This 3D video explains how a signaling pathway begins with the arrival of a chemical signal all the way to the released proteins around the cell.

Tumor Growth
Cancer happens when cells divide uncontrollably and produce a growing lump or tumor. Watch this 3D animation to learn more.

Review Articles:

Models of genetic susceptibility to breast cancer.  Antoniou and Easton, Oncogene. 2006 Sep 25;25(43):5898-905

Mammary cancer susceptibility: human genes and rodent models.  Szpirer and Szpirer, Mamm Genome. 2007 Dec;18(12):817-31

The rat oncogenome: comparative genetics and genomics of rat models of mammary carcinogenesis.  Shull JD  Breast Dis. 2007;28:69-86

Genetically engineered rat models for breast cancer.  Smits et al, Breast Dis. 2007;28:53-61

Sleeping beauty: a novel cancer gene discovery tool.  Dupuy et al, Hum Mol Genet. 2006 Apr 15;15 Spec No 1:R75-9

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