06/08 – RGD now houses genes for the bonoboBonobos, endemic to the Congo Basin, are like other ape species in developing cardiovascular disease that is often a major cause of adult mortality in captive animals. Several important cardiovascular diseases identified in bonobos and other captive ape species include hypertension, cardiomyopathy and fibrosis, congestive heart failure, aortic dissection, stroke, and most recently arrhythmogenic right ventricular cardiomyopathy (ARVC) with associated sudden death. ARVC is a common cause of unexpected sudden cardiac death in humans, accounting for perhaps as many as 17% of sudden deaths in young individuals. Scientists from the Medical College of Wisconsin in cooperation with the Milwaukee County Zoo are trying to identify genetic causes of ARVC in bonobos through the whole genome sequencing analysis. |
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| RGD has incorporated the bonobo (Pan paniscus) into our database. Now when you search for genes at RGD, in addition to results for rat, human, mouse and squirrel, you can access bonobo genes as well.
Once you have one or more bonobo genes, you can use RGD’s Analysis and Visualization tools to explore your gene set. • Use the Bonobo JBrowse genome browser to view the genomic neighborhood for your gene or genes of interest. Bonobo anatomy reveals stasis and mosaicism in chimpanzee evolution, and supports bonobos as the most appropriate extant model for the common ancestor of chimpanzees and humans. Sci Rep. 2017 Apr 4;7(1):608. Diogo R1, Molnar JL2, Wood B3. PMID:28377592 |
