BH3-only Bcl

The BH3-only proteins are initiators of apoptosis. Their on and off activity is regulated at the transcriptional level, by post-translational modification, and/or by protein-protein interactions. Members of the BH3-only family are substrates of many kinases and phosphatases; their expression is under the control of many transcription factors [PMID 19641503 and references therein]. The individual BH3-only members are listed with aliases in parentheses, full names and links to gene report pages:

Bad (Bcl2l8, Bbc2) – BCL2-associated agonist of cell death
Bid – BH3 interacting domain death agonist
Hrk (Dp5) – harakiri, BCL2 interacting protein
Bcl2l11 (Bim, BimL, Bod) – BCL2 like 11
Bnip1 (Nip1, Trg-8) – BCL2 interacting protein 1
Bnip3 (Nip3) – BCL2 interacting protein 3
Bnip3l (Nix, Bnip3a) – BCL2 interacting protein 3 like
Bik (Nbk, Bip1, Bp4) – BCL2-interacting killer
Pmaip1 (Noxa) – phorbol-12-myristate-13-acetate-induced protein 1
Bmf – Bcl2 modifying factor
Bbc3 (Puma, Jfy3) – Bcl-2 binding component 3