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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:Trail mediated signaling pathway
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Accession:PW:0000682 term browser browse the term
Definition:Trail-mediated signaling leads to apoptosis via assembly of the DISC complex (Death-Inducing Signaling Complex) downstream of its receptors.
Synonyms:related_synonym: TRAIL signaling;   TRAIL-activated apoptotic signaling pathway
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Trail mediated signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bid BH3 interacting domain death agonist ISO RGD PMID:17403612 PMID:19961901 RGD:4143170, RGD:4143171 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720 		JBrowse link
G Casp3 caspase 3 ISO RGD PMID:17403612 PMID:19961901 RGD:4143170, RGD:4143171 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp7 caspase 7 ISO RGD PMID:19961901 RGD:4143171 NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729 		JBrowse link
G Casp8 caspase 8 ISO PID
RGD		 PMID:17403612 PMID:19961901 PID:200068, RGD:4143170, RGD:4143171 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator ISO PID
RGD		 PMID:17403612 PMID:19961901 PID:200068, RGD:4143170, RGD:4143171 NCBI chr 9:60,185,338...60,236,173
Ensembl chr 9:60,185,452...60,237,034 		JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex ISO PID PID:200068 NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065 		JBrowse link
G Dap3 death associated protein 3 ISO PID PID:200068 NCBI chr 2:174,319,341...174,347,489
Ensembl chr 2:174,318,983...174,346,461 		JBrowse link
G Fadd Fas associated via death domain ISO PID
RGD		 PMID:17403612 PMID:19961901 PID:200068, RGD:4143170, RGD:4143171 NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653 		JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta ISO PID PID:200068 NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250 		JBrowse link
G Ikbkg inhibitor of nuclear factor kappa B kinase regulatory subunit gamma ISO PID PID:200068 NCBI chr  X:152,216,485...152,241,476
Ensembl chr  X:152,216,596...152,239,499 		JBrowse link
G Map2k4 mitogen activated protein kinase kinase 4 ISO PID PID:200068 NCBI chr10:50,343,227...50,447,956
Ensembl chr10:50,344,915...50,447,993 		JBrowse link
G Map3k1 mitogen-activated protein kinase kinase kinase 1 ISO PID PID:200068 NCBI chr 2:43,348,572...43,414,706
Ensembl chr 2:43,350,098...43,414,463 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 ISO PID PID:200068 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 ISO PID PID:200068 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 ISO PID PID:200068 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha ISO PID PID:200068 NCBI chr 2:115,175,275...115,249,034
Ensembl chr 2:115,174,984...115,249,032 		JBrowse link
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta ISO PID PID:200068 NCBI chr 8:99,594,600...99,699,772
Ensembl chr 8:99,594,644...99,699,663 		JBrowse link
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta ISO PID PID:200068 NCBI chr 5:160,094,952...160,142,962
Ensembl chr 5:160,094,952...160,120,930 		JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 ISO PID PID:200068 NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631 		JBrowse link
G Pik3r2 phosphoinositide-3-kinase regulatory subunit 2 ISO PID PID:200068 NCBI chr16:18,665,517...18,674,067
Ensembl chr16:18,665,457...18,674,065 		JBrowse link
G Pik3r3 phosphoinositide-3-kinase regulatory subunit 3 ISO PID PID:200068 NCBI chr 5:129,700,925...129,772,591
Ensembl chr 5:129,701,229...129,772,583 		JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 ISO PID PID:200068 NCBI chr17:30,839,639...30,871,824
Ensembl chr17:30,839,650...30,871,824 		JBrowse link
G Smpd1 sphingomyelin phosphodiesterase 1 ISO PID PID:200068 NCBI chr 1:159,892,946...159,896,789
Ensembl chr 1:159,892,859...159,896,794 		JBrowse link
G Tnfrsf10b TNF receptor superfamily member 10b IMP
ISO		 PID
RGD		 PMID:19934367 PMID:17403612 PMID:19961901 PID:200068, RGD:4142856, RGD:4143170, RGD:4143171 NCBI chr15:44,840,386...44,868,318
Ensembl chr15:44,840,386...44,867,467 		JBrowse link
G Tnfrsf22 tumor necrosis factor receptor superfamily, member 22 ISO PID PID:200068 NCBI chr 1:198,840,452...198,860,713
Ensembl chr 1:198,840,453...198,856,309 		JBrowse link
G Tnfsf10 TNF superfamily member 10 IMP
ISO		 PID
RGD		 PMID:19385008 PMID:17403612 PMID:19961901 PID:200068, RGD:2312745, RGD:4143170, RGD:4143171 NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135 		JBrowse link
G Tradd TNFRSF1A-associated via death domain ISO PID PID:200068 NCBI chr19:33,136,148...33,142,714
Ensembl chr19:33,136,138...33,142,638 		JBrowse link
G Traf2 Tnf receptor-associated factor 2 ISO PID PID:200068 NCBI chr 3:8,341,950...8,366,609
Ensembl chr 3:8,341,951...8,366,538 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6092
    signaling pathway 2646
      cytokine and chemokine mediated signaling pathway 570
        cytokine mediated signaling pathway 485
          tumor necrosis factor superfamily mediated signaling pathway 88
            Trail mediated signaling pathway 28
              altered Trail mediated signaling pathway 0
Path 2
Term Annotations click to browse term
  pathway 6092
    regulatory pathway 3871
      cell death pathway 243
        programmed cell death pathway 243
          apoptotic cell death pathway 162
            extrinsic apoptotic pathway 88
              Trail mediated signaling pathway 28
                altered Trail mediated signaling pathway 0
paths to the root