PATHWAY ONTOLOGY - ANNOTATIONS
The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml ).
Term: protein kinase A (PKA) signaling pathway
Accession: PW:0000543
browse the term
Definition: Protein kinase A (PKA) signaling is a widely used intracellular pathway and the major route for channeling the cAMP signal. cAMP is regulated by adenylyl cyclases that produce it and phosphodiesterases that hydrolyze it. Compartmentalization of PKA signaling is mediated by the AKAP family of scaffold proteins that bring together the kinase, cAMP modulators and sometimes the targets.
Synonyms: related_synonym: cAMP-dependent protein kinase A signaling pathway; cAMP/PKA signaling pathway; protein kinase A signaling
View Interactive Diagram
G
Adcy1
adenylate cyclase 1
ISO
RGD
PMID:18948702
RGD:2312469
NCBI chr14:81,911,240...82,020,594
Ensembl chr14:81,911,099...82,028,969
G
Adcy10
adenylate cyclase 10
ISO
RGD
PMID:18948702
RGD:2312469
NCBI chr13:77,747,752...77,833,952
Ensembl chr13:77,768,468...77,833,951
G
Adcy2
adenylate cyclase 2
ISO
RGD
PMID:18948702
RGD:2312469
NCBI chr 1:34,375,639...34,822,252
Ensembl chr 1:34,375,895...34,822,236
G
Adcy3
adenylate cyclase 3
ISO
RGD
PMID:18948702
RGD:2312469
NCBI chr 6:27,100,089...27,203,686
Ensembl chr 6:27,124,828...27,203,686
G
Adcy4
adenylate cyclase 4
ISO
RGD
PMID:18948702
RGD:2312469
NCBI chr15:29,266,280...29,282,153
Ensembl chr15:29,266,287...29,282,108
G
Adcy5
adenylate cyclase 5
ISO
RGD
PMID:18948702
RGD:2312469
NCBI chr11:65,471,612...65,618,877
Ensembl chr11:65,471,612...65,618,974
G
Adcy6
adenylate cyclase 6
ISO IDA
RGD
PMID:18948702 PMID:15579502
RGD:2312469 , RGD:2313211
NCBI chr 7:129,742,827...129,763,922
Ensembl chr 7:129,742,838...129,763,754
G
Adcy7
adenylate cyclase 7
ISO
RGD
PMID:18948702
RGD:2312469
NCBI chr19:18,740,875...18,798,924
Ensembl chr19:18,740,875...18,776,311
G
Adcy8
adenylate cyclase 8
ISO
RGD
PMID:18948702
RGD:2312469
NCBI chr 7:96,417,310...96,665,911
Ensembl chr 7:96,417,324...96,665,911
G
Adcy9
adenylate cyclase 9
ISO
RGD
PMID:18948702
RGD:2312469
NCBI chr10:11,138,966...11,262,067
Ensembl chr10:11,139,446...11,262,066
G
Akap1
A-kinase anchoring protein 1
ISO
RGD
PMID:14715913 PMID:19319965
RGD:2312475 , RGD:2312477
NCBI chr10:73,621,021...73,654,123
Ensembl chr10:73,621,883...73,653,896
G
Akap10
A-kinase anchoring protein 10
ISO
RGD
PMID:14715913 PMID:19319965
RGD:2312475 , RGD:2312477
NCBI chr10:46,545,371...46,608,730
Ensembl chr10:46,551,532...46,608,769
G
Akap11
A-kinase anchoring protein 11
ISO IMP
RGD
PMID:14715913 PMID:19319965 PMID:18385542
RGD:2312475 , RGD:2312477 , RGD:2312637
NCBI chr15:53,911,635...53,956,138
Ensembl chr15:53,911,657...53,941,605
G
Akap12
A-kinase anchoring protein 12
ISO
RGD
PMID:14715913 PMID:19319965
RGD:2312475 , RGD:2312477
NCBI chr 1:40,730,123...40,819,863
Ensembl chr 1:40,730,123...40,819,886
G
Akap13
A-kinase anchoring protein 13
ISO
RGD
PMID:14715913 PMID:19319965
RGD:2312475 , RGD:2312477
NCBI chr 1:129,313,183...129,619,647
Ensembl chr 1:129,314,402...129,619,646
G
Akap14
A-kinase anchoring protein 14
ISO
RGD
PMID:14715913 PMID:19319965
RGD:2312475 , RGD:2312477
NCBI chr X:116,395,512...116,410,697
Ensembl chr X:116,395,516...116,410,697
G
Akap3
A-kinase anchoring protein 3
ISO
RGD
PMID:14715913 PMID:19319965
RGD:2312475 , RGD:2312477
NCBI chr 4:159,688,049...159,714,067
Ensembl chr 4:159,699,289...159,713,903
G
Akap4
A-kinase anchoring protein 4
ISO
RGD
PMID:14715913 PMID:19319965
RGD:2312475 , RGD:2312477
NCBI chr X:15,435,391...15,445,684
Ensembl chr X:15,435,410...15,445,684
G
Akap5
A-kinase anchoring protein 5
ISO
RGD
PMID:14715913 PMID:19319965
RGD:2312475 , RGD:2312477
NCBI chr 6:95,051,527...95,061,075
Ensembl chr 6:95,051,537...95,061,578
G
Akap6
A-kinase anchoring protein 6
ISO IMP
RGD
PMID:14715913 PMID:19319965 PMID:11296225
RGD:2312475 , RGD:2312477 , RGD:68716
NCBI chr 6:70,184,101...70,624,369
Ensembl chr 6:70,184,175...70,619,738
G
Akap7
A-kinase anchoring protein 7
ISO IMP
RGD
PMID:14715913 PMID:19319965 PMID:17901878
RGD:2312475 , RGD:2312477 , RGD:2312630
NCBI chr 1:20,087,190...20,217,799
Ensembl chr 1:20,087,373...20,217,797
G
Akap8
A-kinase anchoring protein 8
ISO
RGD
PMID:14715913 PMID:19319965
RGD:2312475 , RGD:2312477
NCBI chr 7:11,316,224...11,332,523
Ensembl chr 7:11,316,228...11,332,399
G
Akap9
A-kinase anchoring protein 9
ISO
RGD
PMID:14715913 PMID:19319965
RGD:2312475 , RGD:2312477
NCBI chr 4:30,056,738...30,192,716
Ensembl chr 4:30,056,738...30,192,606
G
Crhr2
corticotropin releasing hormone receptor 2
IMP
RGD
PMID:15911134
RGD:5131271
NCBI chr 4:84,222,897...84,265,924
Ensembl chr 4:84,224,002...84,265,904
G
Ezr
ezrin
ISO
RGD
PMID:14715913
RGD:2312475
NCBI chr 1:46,967,961...47,011,505
Ensembl chr 1:46,967,658...47,011,505
G
Pakap
paralemmin A kinase anchor protein
ISO
RGD
PMID:14715913 PMID:19319965
RGD:2312475 , RGD:2312477
NCBI chr 5:72,536,986...72,648,524 NCBI chr 5:72,313,646...72,450,645
Ensembl chr 5:72,181,718...72,648,524
G
Pde10a
phosphodiesterase 10A
ISO
RGD
PMID:17376027
RGD:2312479
NCBI chr 1:51,765,743...52,218,086
Ensembl chr 1:51,770,132...52,216,563
G
Pde11a
phosphodiesterase 11A
ISO
RGD
PMID:17376027
RGD:2312479
NCBI chr 3:60,913,562...61,297,154
Ensembl chr 3:60,913,562...61,297,158
G
Pde1a
phosphodiesterase 1A
ISO
RGD
PMID:17376027
RGD:2312479
NCBI chr 3:64,745,140...65,025,178
Ensembl chr 3:64,747,269...65,024,874
G
Pde1b
phosphodiesterase 1B
ISO
RGD
PMID:17376027
RGD:2312479
NCBI chr 7:134,627,378...134,654,581
Ensembl chr 7:134,627,322...134,654,580
G
Pde1c
phosphodiesterase 1C
ISO
RGD
PMID:17376027
RGD:2312479
NCBI chr 4:85,300,858...85,777,948
Ensembl chr 4:85,300,858...85,863,219
G
Pde2a
phosphodiesterase 2A
ISO
RGD
PMID:17376027
RGD:2312479
NCBI chr 1:155,823,590...155,915,434
Ensembl chr 1:155,813,180...155,915,434
G
Pde3a
phosphodiesterase 3A
ISO
RGD
PMID:17376027 PMID:17376027
RGD:2312479 , RGD:2312479
NCBI chr 4:174,172,804...174,443,944
Ensembl chr 4:174,172,868...174,438,274
G
Pde3b
phosphodiesterase 3B
ISO
RGD
PMID:17376027
RGD:2312479
NCBI chr 1:168,606,762...168,770,078
Ensembl chr 1:168,607,022...168,769,334
G
Pde4a
phosphodiesterase 4A
ISO
RGD
PMID:17376027
RGD:2312479
NCBI chr 8:19,690,816...19,753,538
Ensembl chr 8:19,703,290...19,751,961
G
Pde4b
phosphodiesterase 4B
ISO
RGD
PMID:17376027
RGD:2312479
NCBI chr 5:116,799,819...117,369,155
Ensembl chr 5:116,799,971...117,367,696
G
Pde4c
phosphodiesterase 4C
ISO
RGD
PMID:17376027
RGD:2312479
NCBI chr16:18,690,727...18,711,555
Ensembl chr16:18,691,700...18,710,640
G
Pde4d
phosphodiesterase 4D
ISO IMP
RGD
PMID:17376027 PMID:11296225
RGD:2312479 , RGD:68716
NCBI chr 2:40,014,933...41,529,190
Ensembl chr 2:40,019,933...41,525,884
G
Pde7a
phosphodiesterase 7A
ISO
RGD
PMID:17376027
RGD:2312479
NCBI chr 2:101,714,767...101,806,853
Ensembl chr 2:101,718,444...101,806,681
G
Pde7b
phosphodiesterase 7B
ISO
RGD
PMID:17376027
RGD:2312479
NCBI chr 1:15,174,001...15,493,267
Ensembl chr 1:15,182,704...15,492,900
G
Pde8a
phosphodiesterase 8A
ISO
RGD
PMID:17376027
RGD:2312479
NCBI chr 1:135,166,143...135,288,986
Ensembl chr 1:135,166,237...135,288,024
G
Pde8b
phosphodiesterase 8B
ISO
RGD
PMID:17376027
RGD:2312479
NCBI chr 2:26,275,117...26,479,725
Ensembl chr 2:26,276,635...26,509,209
G
Prkaca
protein kinase cAMP-activated catalytic subunit alpha
ISO
RGD
PMID:14715913
RGD:2312475
NCBI chr19:24,155,081...24,178,430
Ensembl chr19:24,155,090...24,178,430
G
Prkacb
protein kinase cAMP-activated catalytic subunit beta
ISO
RGD
PMID:14715913
RGD:2312475
NCBI chr 2:235,636,878...235,726,928
Ensembl chr 2:235,636,885...235,726,198
G
Prkar1a
protein kinase cAMP-dependent type I regulatory subunit alpha
ISO
RGD
PMID:14715913
RGD:2312475
NCBI chr10:94,621,042...94,639,534
Ensembl chr10:94,620,039...94,639,041
G
Prkar1b
protein kinase cAMP-dependent type I regulatory subunit beta
ISO
RGD
PMID:14715913
RGD:2312475
NCBI chr12:15,492,233...15,624,942
Ensembl chr12:15,511,801...15,624,942
G
Prkar2a
protein kinase cAMP-dependent type II regulatory subunit alpha
ISO
RGD
PMID:14715913
RGD:2312475
NCBI chr 8:109,393,189...109,458,832
Ensembl chr 8:109,395,833...109,455,628
G
Prkar2b
protein kinase cAMP-dependent type II regulatory subunit beta
ISO
RGD
PMID:14715913
RGD:2312475
NCBI chr 6:48,563,659...48,653,933
Ensembl chr 6:48,563,662...48,653,933
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all