Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:epidermal growth factor/neuregulin signaling pathway
go back to main search page
Accession:PW:0000170 term browser browse the term
Definition:Members of the EGF/neuregulin superfamily are important regulators of tissue development and repair. A characteristic feature is the presence of the EGF module, a 36-40 amino acid sequence with a disulfide-bonded three-loop structure necessary for receptor binding.
Synonyms:related_synonym: EGF/neuregulin signaling pathway;   Signaling by EGFR;   epidermal growth factor receptor signaling pathway
View Interactive Diagram


show annotations for term's descendants           Sort by:
epidermal growth factor/neuregulin signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase IEA KEGG rno:04012 NCBI chr 3:14,979,853...15,083,065
Ensembl chr 3:14,979,853...15,083,065 		JBrowse link
G Abl2 ABL proto-oncogene 2, non-receptor tyrosine kinase IEA KEGG rno:04012 NCBI chr13:68,673,702...68,770,846
Ensembl chr13:68,673,722...68,839,742 		JBrowse link
G Adam10 ADAM metallopeptidase domain 10 ISO RGD PMID:15688065 RGD:2317976 NCBI chr 8:71,346,008...71,477,889
Ensembl chr 8:71,345,837...71,477,889 		JBrowse link
G Adam12 ADAM metallopeptidase domain 12 ISO RGD PMID:15688065 RGD:2317976 NCBI chr 1:188,686,984...189,014,206
Ensembl chr 1:188,686,989...189,020,667 		JBrowse link
G Adam17 ADAM metallopeptidase domain 17 ISO RGD PMID:15688065 RGD:2317976 NCBI chr 6:40,872,936...40,920,700
Ensembl chr 6:40,872,856...40,920,639 		JBrowse link
G Adam19 ADAM metallopeptidase domain 19 ISO RGD PMID:15688065 RGD:2317976 NCBI chr10:30,491,362...30,583,115
Ensembl chr10:30,491,405...30,583,105 		JBrowse link
G Adam9 ADAM metallopeptidase domain 9 ISO RGD PMID:15688065 RGD:2317976 NCBI chr16:67,022,538...67,101,647
Ensembl chr16:67,022,655...67,100,917 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 IEA KEGG rno:04012 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Akt2 AKT serine/threonine kinase 2 IEA KEGG rno:04012 NCBI chr 1:82,877,228...82,933,828
Ensembl chr 1:82,883,547...82,933,817 		JBrowse link
G Akt3 AKT serine/threonine kinase 3 IEA KEGG rno:04012 NCBI chr13:88,943,708...89,225,831
Ensembl chr13:88,946,091...89,225,708 		JBrowse link
G Areg amphiregulin IDA
ISO
IEA		 PID
KEGG
RGD		 PMID:15509566 PMID:15982853 PID:200159 rno:04012, RGD:1578718, RGD:2317963 NCBI chr14:16,972,185...16,981,443
Ensembl chr14:16,972,187...16,981,535 		JBrowse link
G Bad BCL2-associated agonist of cell death IEA KEGG rno:04012 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823 		JBrowse link
G Braf B-Raf proto-oncogene, serine/threonine kinase IEA KEGG rno:04012 NCBI chr 4:68,375,484...68,510,652
Ensembl chr 4:68,384,649...68,510,463 		JBrowse link
G Btc betacellulin ISO
IEA
IDA		 KEGG
PID
RGD		 PMID:15982853 PMID:11564606 PID:200159 rno:04012, RGD:2317963, RGD:2324625 NCBI chr14:16,708,447...16,746,961
Ensembl chr14:16,707,982...16,747,049 		JBrowse link
G Camk2a calcium/calmodulin-dependent protein kinase II alpha IEA KEGG rno:04012 NCBI chr18:54,378,642...54,441,120
Ensembl chr18:54,378,784...54,438,994 		JBrowse link
G Camk2b calcium/calmodulin-dependent protein kinase II beta IEA KEGG rno:04012 NCBI chr14:80,845,206...80,934,172
Ensembl chr14:80,845,238...80,933,994 		JBrowse link
G Camk2d calcium/calmodulin-dependent protein kinase II delta IEA KEGG rno:04012 NCBI chr 2:215,023,785...215,287,351
Ensembl chr 2:215,024,004...215,286,178 		JBrowse link
G Camk2g calcium/calmodulin-dependent protein kinase II gamma IEA KEGG rno:04012 NCBI chr15:3,504,017...3,563,050
Ensembl chr15:3,504,085...3,563,050 		JBrowse link
G Cbl Cbl proto-oncogene ISO
IEA		 KEGG
RGD		 PMID:16829981 rno:04012, RGD:2317988 NCBI chr 8:44,487,824...44,571,620
Ensembl chr 8:44,489,410...44,571,176 		JBrowse link
G Cblb Cbl proto-oncogene B IEA KEGG rno:04012 NCBI chr11:48,589,878...48,756,940
Ensembl chr11:48,592,703...48,756,839 		JBrowse link
G Cblc Cbl proto-oncogene C IEA KEGG rno:04012 NCBI chr 1:79,439,975...79,456,755
Ensembl chr 1:79,439,977...79,456,755 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A IEA KEGG rno:04012 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B IEA KEGG rno:04012 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982 		JBrowse link
G Crk CRK proto-oncogene, adaptor protein IEA KEGG rno:04012 NCBI chr10:60,530,469...60,556,703
Ensembl chr10:60,530,464...60,553,406 		JBrowse link
G Crkl CRK like proto-oncogene, adaptor protein IEA KEGG rno:04012 NCBI chr11:83,528,788...83,563,214
Ensembl chr11:83,526,530...83,563,238 		JBrowse link
G Egf epidermal growth factor IDA
IEA
ISO		 KEGG
PID
RGD		 PMID:2260661 PMID:15982853 PID:200101 PID:200159 rno:04012, RGD:1626483, RGD:2317963 NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064 		JBrowse link
G Egfr epidermal growth factor receptor IMP
IEA
ISO		 KEGG
PID
RGD		 PMID:16648628 PMID:15486316 PMID:15982853 PID:200101 PID:200159 rno:04012, RGD:1581898, RGD:1581908, RGD:2317963 NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382 		JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 IEA KEGG rno:04012 NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984 		JBrowse link
G Elk1 ETS transcription factor ELK1 IEA KEGG rno:04012 NCBI chr  X:1,138,826...1,155,713
Ensembl chr  X:1,139,756...1,155,713 		JBrowse link
G Epgn epithelial mitogen ISO RGD PMID:15982853 RGD:2317963 NCBI chr14:17,076,774...17,084,806
Ensembl chr14:17,076,774...17,084,806 		JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 ISO
IEA		 KEGG
PID
RGD		 PMID:15982853 PID:200159 rno:04012, RGD:2317963 NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078 		JBrowse link
G Erbb3 erb-b2 receptor tyrosine kinase 3 IMP
IEA
ISO		 Neuregulin stimulation of glucose transport in muscle cells KEGG
PID
RGD		 PMID:15007074 PMID:14711829 PMID:16829981 PMID:18519747 PID:200159 rno:04012, RGD:1642700, RGD:2289958, RGD:2317988, RGD:2317965 NCBI chr 7:994,549...1,015,876
Ensembl chr 7:996,225...1,015,525 		JBrowse link
G Erbb4 erb-b2 receptor tyrosine kinase 4 ISO
IEA		 KEGG
RGD		 PMID:18519747 rno:04012, RGD:2317965 NCBI chr 9:69,523,733...70,596,743
Ensembl chr 9:69,531,481...70,596,595 		JBrowse link
G Ereg epiregulin ISO
IEA		 KEGG
PID
RGD		 PMID:15982853 PID:200159 rno:04012, RGD:2317963 NCBI chr14:17,027,287...17,041,062
Ensembl chr14:17,027,287...17,041,062 		JBrowse link
G Gab1 GRB2-associated binding protein 1 ISO
IEA		 PID
KEGG		 PID:200101 rno:04012 NCBI chr19:27,131,262...27,239,236
Ensembl chr19:27,131,262...27,239,236 		JBrowse link
G Gnai1 G protein subunit alpha i1 ISO PID PID:200101 NCBI chr 4:16,814,000...16,898,119
Ensembl chr 4:16,814,001...16,896,417 		JBrowse link
G Gnai3 G protein subunit alpha i3 ISO PID PID:200101 NCBI chr 2:195,742,765...195,780,720
Ensembl chr 2:195,742,642...195,780,742 		JBrowse link
G Gper1 G protein-coupled estrogen receptor 1 IMP RGD PMID:20445128 RGD:4892084 NCBI chr12:15,217,217...15,222,679
Ensembl chr12:15,217,442...15,221,889 		JBrowse link
G Grb2 growth factor receptor bound protein 2 ISO
IEA		 KEGG
PID
RGD		 PMID:16829981 PID:200101 rno:04012, RGD:2317988 NCBI chr10:100,881,404...100,949,193
Ensembl chr10:100,869,718...100,949,309 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta IEA KEGG rno:04012 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Gsn gelsolin ISO PID PID:200101 NCBI chr 3:18,585,166...18,638,404
Ensembl chr 3:18,585,172...18,638,402 		JBrowse link
G Hbegf heparin-binding EGF-like growth factor ISO
IMP
IEA		 PID
KEGG
RGD		 PMID:15982853 PMID:15486316 PID:200159 rno:04012, RGD:2317963, RGD:1581908 NCBI chr18:28,106,284...28,116,167
Ensembl chr18:28,105,760...28,116,441 		JBrowse link
G Hras HRas proto-oncogene, GTPase ISO
IEA		 PID
KEGG		 PID:200101 rno:04012 NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615 		JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 ISO PID PID:200159 NCBI chr 6:129,702,376...129,707,907
Ensembl chr 6:129,702,383...129,707,268 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit IEA KEGG rno:04012 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Kras KRAS proto-oncogene, GTPase IEA KEGG rno:04012 NCBI chr 4:178,185,418...178,218,484 JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 IEA KEGG rno:04012 NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147 		JBrowse link
G Map2k2 mitogen activated protein kinase kinase 2 IEA KEGG rno:04012 NCBI chr 7:8,590,729...8,610,279
Ensembl chr 7:8,580,905...8,610,243 		JBrowse link
G Map2k4 mitogen activated protein kinase kinase 4 IEA KEGG rno:04012 NCBI chr10:50,343,227...50,447,956
Ensembl chr10:50,344,915...50,447,993 		JBrowse link
G Map2k7 mitogen activated protein kinase kinase 7 IEA KEGG rno:04012 NCBI chr12:2,591,312...2,600,534
Ensembl chr12:2,591,219...2,604,222 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 ISO
IEA		 PID
KEGG		 PID:200101 rno:04012 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk10 mitogen activated protein kinase 10 IEA KEGG rno:04012 NCBI chr14:6,497,662...6,790,109
Ensembl chr14:6,497,707...6,786,201 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 ISO
IEA		 PID
KEGG		 PID:200101 rno:04012 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 IEA KEGG rno:04012 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 IEA KEGG rno:04012 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178 		JBrowse link
G Mtor mechanistic target of rapamycin kinase IEA KEGG rno:04012 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor IEA KEGG rno:04012 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Nck1 NCK adaptor protein 1 ISO
IEA		 PID
KEGG		 PID:200101 rno:04012 NCBI chr 8:101,018,610...101,079,237
Ensembl chr 8:101,018,702...101,079,300 		JBrowse link
G Nck2 NCK adaptor protein 2 ISO
IEA		 PID
KEGG		 PID:200101 rno:04012 NCBI chr 9:45,713,979...45,840,330
Ensembl chr 9:45,714,883...45,840,307 		JBrowse link
G Nras NRAS proto-oncogene, GTPase ISO
IEA		 PID
KEGG		 PID:200101 rno:04012 NCBI chr 2:190,582,885...190,593,509
Ensembl chr 2:190,582,918...190,591,626 		JBrowse link
G Nrg1 neuregulin 1 ISO
IEA		 KEGG
RGD		 PMID:18519747 rno:04012, RGD:2317965 NCBI chr16:59,250,658...60,304,519
Ensembl chr16:59,250,854...60,296,884 		JBrowse link
G Nrg2 neuregulin 2 IDA
IEA
ISO		 KEGG
PID
RGD		 PMID:9348101 PMID:18519747 PID:200159 rno:04012, RGD:1304015, RGD:2317965 NCBI chr18:27,616,542...27,798,505
Ensembl chr18:27,619,661...27,798,505 		JBrowse link
G Nrg3 neuregulin 3 ISO
IEA		 KEGG
PID
RGD		 PMID:18519747 PID:200159 rno:04012, RGD:2317965 NCBI chr16:14,229,270...15,352,505
Ensembl chr16:14,235,157...15,352,368 		JBrowse link
G Nrg4 neuregulin 4 ISO
IEA		 KEGG
PID
RGD		 PMID:18519747 PID:200159 rno:04012, RGD:2317965 NCBI chr 8:55,586,253...55,677,829
Ensembl chr 8:55,592,893...55,677,483 		JBrowse link
G Pak1 p21 (RAC1) activated kinase 1 ISO
IEA		 PID
KEGG		 PID:200101 rno:04012 NCBI chr 1:152,111,172...152,226,390
Ensembl chr 1:152,111,188...152,226,383 		JBrowse link
G Pak2 p21 (RAC1) activated kinase 2 IEA KEGG rno:04012 NCBI chr11:68,707,940...68,768,816
Ensembl chr11:68,707,969...68,768,816 		JBrowse link
G Pak3 p21 (RAC1) activated kinase 3 IEA KEGG rno:04012 NCBI chr  X:107,116,308...107,374,342
Ensembl chr  X:107,260,898...107,368,314 		JBrowse link
G Pak4 p21 (RAC1) activated kinase 4 IEA KEGG rno:04012 NCBI chr 1:83,849,904...83,889,188
Ensembl chr 1:83,849,904...83,859,413 		JBrowse link
G Pak5 p21 (RAC1) activated kinase 5 IEA KEGG rno:04012 NCBI chr 3:123,395,678...123,703,967
Ensembl chr 3:123,396,497...123,703,930 		JBrowse link
G Pak6 p21 (RAC1) activated kinase 6 IEA KEGG rno:04012 NCBI chr 3:105,638,248...105,674,399
Ensembl chr 3:105,638,653...105,672,975 		JBrowse link
G Pdk1 pyruvate dehydrogenase kinase 1 IMP Neuregulin stimulation of glucose transport in muscle cells RGD PMID:15007074 RGD:1642700 NCBI chr 3:56,705,824...56,733,040
Ensembl chr 3:56,705,871...56,733,038 		JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha ISO
IEA		 PID
KEGG		 PID:200101 rno:04012 NCBI chr 2:115,175,275...115,249,034
Ensembl chr 2:115,174,984...115,249,032 		JBrowse link
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta ISO
IEA		 PID
KEGG		 PID:200101 rno:04012 NCBI chr 8:99,594,600...99,699,772
Ensembl chr 8:99,594,644...99,699,663 		JBrowse link
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta ISO
IEA		 PID
KEGG		 PID:200101 rno:04012 NCBI chr 5:160,094,952...160,142,962
Ensembl chr 5:160,094,952...160,120,930 		JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 ISO
IEA		 KEGG
PID
RGD		 PMID:16829981 PID:200101 rno:04012, RGD:2317988 NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631 		JBrowse link
G Pik3r2 phosphoinositide-3-kinase regulatory subunit 2 ISO
IEA		 PID
KEGG		 PID:200101 rno:04012 NCBI chr16:18,665,517...18,674,067
Ensembl chr16:18,665,457...18,674,065 		JBrowse link
G Pik3r3 phosphoinositide-3-kinase regulatory subunit 3 ISO
IEA		 PID
KEGG		 PID:200101 rno:04012 NCBI chr 5:129,700,925...129,772,591
Ensembl chr 5:129,701,229...129,772,583 		JBrowse link
G Pik3r5 phosphoinositide-3-kinase, regulatory subunit 5 IEA KEGG rno:04012 NCBI chr10:53,132,585...53,200,663
Ensembl chr10:53,132,603...53,199,374 		JBrowse link
G Pip5k1c phosphatidylinositol-4-phosphate 5-kinase type 1 gamma ISO PID PID:200101 NCBI chr 7:8,397,406...8,426,030
Ensembl chr 7:8,397,406...8,425,988 		JBrowse link
G Plcg1 phospholipase C, gamma 1 ISO
IEA		 PID
KEGG		 PID:200101 rno:04012 NCBI chr 3:149,385,587...149,416,330
Ensembl chr 3:149,385,587...149,416,330 		JBrowse link
G Plcg2 phospholipase C, gamma 2 IEA KEGG rno:04012 NCBI chr19:45,547,416...45,683,930
Ensembl chr19:45,547,416...45,683,930 		JBrowse link
G Prkca protein kinase C, alpha IEA KEGG rno:04012 NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012 		JBrowse link
G Prkcb protein kinase C, beta IEA KEGG rno:04012 NCBI chr 1:176,832,173...177,163,539
Ensembl chr 1:176,832,226...177,163,536 		JBrowse link
G Prkcg protein kinase C, gamma IEA KEGG rno:04012 NCBI chr 1:65,832,851...65,860,676
Ensembl chr 1:65,832,855...65,859,384 		JBrowse link
G Prkcz protein kinase C, zeta IMP Neuregulin stimulation of glucose transport in muscle cells RGD PMID:15007074 RGD:1642700 NCBI chr 5:165,817,786...165,930,386
Ensembl chr 5:165,819,466...165,930,367 		JBrowse link
G Ptk2 protein tyrosine kinase 2 IEA KEGG rno:04012 NCBI chr 7:105,126,725...105,331,848
Ensembl chr 7:105,126,728...105,331,783 		JBrowse link
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 ISO PID PID:200101 NCBI chr 3:156,638,811...156,687,503
Ensembl chr 3:156,638,769...156,687,504 		JBrowse link
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 ISO PID PID:200101 NCBI chr12:35,365,436...35,424,925
Ensembl chr12:35,383,144...35,424,925 		JBrowse link
G Ptpn6 protein tyrosine phosphatase, non-receptor type 6 ISO PID PID:200101 NCBI chr 4:157,526,034...157,550,783
Ensembl chr 4:157,526,035...157,550,984 		JBrowse link
G Ptprj protein tyrosine phosphatase, receptor type, J ISO RGD PMID:16829981 RGD:2317988 NCBI chr 3:76,405,917...76,561,842
Ensembl chr 3:76,405,927...76,562,260 		JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase IEA KEGG rno:04012 NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317 		JBrowse link
G Rasa1 RAS p21 protein activator 1 ISO PID PID:200101 NCBI chr 2:15,857,704...15,940,757
Ensembl chr 2:15,857,980...15,940,854 		JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 IEA KEGG rno:04012 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908 		JBrowse link
G Rps6kb2 ribosomal protein S6 kinase B2 IEA KEGG rno:04012 NCBI chr 1:201,451,265...201,458,096
Ensembl chr 1:201,451,265...201,458,078 		JBrowse link
G Shc1 SHC adaptor protein 1 ISO
IEA		 KEGG
RGD		 PMID:16829981 rno:04012, RGD:2317988 NCBI chr 2:174,837,937...174,849,538
Ensembl chr 2:174,837,930...174,849,536 		JBrowse link
G Shc2 SHC adaptor protein 2 IEA KEGG rno:04012 NCBI chr 7:10,066,705...10,088,926
Ensembl chr 7:10,066,705...10,088,926 		JBrowse link
G Shc3 SHC adaptor protein 3 IEA KEGG rno:04012 NCBI chr17:13,652,247...13,772,710
Ensembl chr17:13,651,202...13,772,710 		JBrowse link
G Shc4 SHC adaptor protein 4 IEA KEGG rno:04012 NCBI chr 3:112,880,598...112,974,216
Ensembl chr 3:112,880,600...112,974,366 		JBrowse link
G Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 IEP
IEA
ISO		 KEGG
PID
RGD		 PMID:8577724 PMID:16829981 PID:200101 rno:04012, RGD:1581110, RGD:2317988 NCBI chr 6:14,533,870...14,613,348
Ensembl chr 6:14,533,360...14,611,107 		JBrowse link
G Sos2 SOS Ras/Rho guanine nucleotide exchange factor 2 ISO
IEA		 KEGG
RGD		 PMID:16829981 rno:04012, RGD:2317988 NCBI chr 6:88,042,966...88,156,140
Ensembl chr 6:88,042,966...88,156,692 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase IEP
IEA
ISO		 KEGG
PID
RGD		 PMID:15856020 PID:200101 rno:04012, RGD:1581134 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476 		JBrowse link
G Stat1 signal transducer and activator of transcription 1 ISO PID PID:200101 NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 ISO PID PID:200101 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Stat5a signal transducer and activator of transcription 5A IEA KEGG rno:04012 NCBI chr10:85,785,537...85,809,869
Ensembl chr10:85,785,537...85,809,866 		JBrowse link
G Stat5b signal transducer and activator of transcription 5B IEA KEGG rno:04012 NCBI chr10:85,704,841...85,775,856
Ensembl chr10:85,705,670...85,775,668 		JBrowse link
G Tgfa transforming growth factor alpha ISO
IEA		 KEGG
PID
RGD		 PMID:15982853 PID:200159 rno:04012, RGD:2317963 NCBI chr 4:118,618,043...118,700,897
Ensembl chr 4:118,618,269...118,700,894 		JBrowse link
G Tln1 talin 1 ISO PID PID:200101 NCBI chr 5:57,787,670...57,817,900
Ensembl chr 5:57,787,943...57,817,900 		JBrowse link
G Wasl WASP like actin nucleation promoting factor ISO PID PID:200101 NCBI chr 4:53,083,536...53,132,061
Ensembl chr 4:53,083,536...53,132,022 		JBrowse link
altered epidermal growth factor/neuregulin signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Egf epidermal growth factor ISO RGD PMID:19506583 RGD:5490965 NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064 		JBrowse link
G Egfr epidermal growth factor receptor ISO RGD PMID:20519133 PMID:20951313 PMID:19506583 RGD:5133241, RGD:5133242, RGD:5490965 NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382 		JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 ISO RGD PMID:19078924 PMID:21277552 RGD:4143515, RGD:5133243 NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078 		JBrowse link
G Tgfa transforming growth factor alpha ISO RGD PMID:19506583 RGD:5490965 NCBI chr 4:118,618,043...118,700,897
Ensembl chr 4:118,618,269...118,700,894 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6092
    signaling pathway 2646
      growth factor signaling pathway 523
        epidermal growth factor/neuregulin signaling pathway 108
          altered epidermal growth factor/neuregulin signaling pathway 4
paths to the root