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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (https://rgd.mcw.edu/rgdweb/contact/contactus.html).
Term:tamoxifen pharmacodynamics pathway
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Accession:PW:0000839 term browser browse the term
Definition:The pathway of tamoxifen-target interaction and of the biochemical or physiological responses to drug. In breast cancer cells, tamoxifen binding antagonizes estrogen binding and the subsequent conformational changes necessary for co-activators recruitment. It may also prompt the recruitment of co-repressor. Genetic variations can cause differences in the response of the organism to the drug.
Synonyms:related_synonym: SMP:00471
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tamoxifen pharmacodynamics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 ISO SMPDB SMP:00471 NCBI chr 1:90,780,468...90,859,852 JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 ISO SMPDB SMP:00471 NCBI chr 7:115,762,662...115,771,832
Ensembl chr 7:115,761,696...115,771,837 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 ISO SMPDB SMP:00471 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857 		JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 ISO SMPDB SMP:00471 NCBI chr12:21,919,955...21,960,160
Ensembl chr12:21,919,940...21,960,154 		JBrowse link
G Esr1 estrogen receptor 1 ISO SMPDB
RGD		 PMID:19629072 SMP:00471, RGD:5130191 NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:43,644,392...43,900,354 		JBrowse link
G Esr2 estrogen receptor 2 ISO RGD PMID:19629072 RGD:5130191 NCBI chr 6:100,589,553...100,645,240
Ensembl chr 6:100,545,206...100,644,709 		JBrowse link
G Fmo1 flavin containing dimethylaniline monoxygenase 1 ISO SMPDB SMP:00471 NCBI chr13:77,715,405...77,747,666
Ensembl chr13:77,715,402...77,747,874 		JBrowse link
G Fmo3 flavin containing dimethylaniline monoxygenase 3 ISO SMPDB SMP:00471 NCBI chr13:77,838,899...77,868,869
Ensembl chr13:77,842,602...77,861,256 		JBrowse link
G Ncoa3 nuclear receptor coactivator 3 ISO RGD PMID:16822624 RGD:5130718 NCBI chr 3:175,157,824...175,237,831
Ensembl chr 3:175,157,821...175,240,631 		JBrowse link
G Ncor1 nuclear receptor co-repressor 1 ISO RGD PMID:16822624 RGD:5130718 NCBI chr10:47,498,852...47,641,612
Ensembl chr10:47,498,852...47,640,350 		JBrowse link
G Ncor2 nuclear receptor co-repressor 2 ISO RGD PMID:16822624 RGD:5130718 NCBI chr12:37,127,736...37,289,612
Ensembl chr12:37,127,686...37,289,612 		JBrowse link
G Phb2 prohibitin 2 ISO RGD PMID:16822624 RGD:5130718 NCBI chr 4:159,203,948...159,208,561
Ensembl chr 4:159,203,926...159,209,231 		JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 ISO SMPDB SMP:00471 NCBI chr 1:190,702,592...190,706,112
Ensembl chr 1:190,702,592...190,706,131 		JBrowse link
G Ugt1a5 UDP glucuronosyltransferase family 1 member A5 ISO SMPDB SMP:00471 NCBI chr 9:96,210,053...96,256,264
Ensembl chr 9:96,144,786...96,256,264 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6091
    drug pathway 397
      antineoplastic and immunomodulatory drug pathway 156
        antineoplastic drug pathway 154
          anti-estrogen drug pathway 26
            tamoxifen drug pathway 25
              tamoxifen pharmacodynamics pathway 14
paths to the root