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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (https://rgd.mcw.edu/rgdweb/contact/contactus.html).
Term:sterol regulatory element-binding protein signaling pathway
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Accession:PW:0000753 term browser browse the term
Definition:The sterol regulatory element-binding protein (SREBP) pathway has important roles in the control of lipid and cholesterol metabolism. SREBPs are sterol-regulated transcription factors that belong to the bHLH family.
Synonyms:related_synonym: SREBP signaling pathway
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sterol regulatory element-binding protein signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Insig1 insulin induced gene 1 ISO RGD PMID:19933148 RGD:2317203 NCBI chr 4:8,049,339...8,057,812
Ensembl chr 4:8,049,556...8,057,778 		JBrowse link
G Insig2 insulin induced gene 2 ISO RGD PMID:19933148 RGD:2317203 NCBI chr13:35,025,160...35,052,937
Ensembl chr13:35,025,164...35,047,658 		JBrowse link
G Mbtps1 membrane-bound transcription factor peptidase, site 1 ISO RGD PMID:19933148 RGD:2317203 NCBI chr19:64,470,245...64,521,438
Ensembl chr19:64,470,545...64,521,342 		JBrowse link
G Mbtps2 membrane-bound transcription factor peptidase, site 2 ISO RGD PMID:19933148 RGD:2317203 NCBI chr  X:41,225,956...41,290,030
Ensembl chr  X:41,254,335...41,277,701 		JBrowse link
G Scap SREBF chaperone ISO RGD PMID:19933148 RGD:2317203 NCBI chr 8:119,184,366...119,239,086
Ensembl chr 8:119,184,438...119,239,075 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 ISO RGD PMID:19933148 RGD:2317203 NCBI chr10:45,507,152...45,529,164
Ensembl chr10:45,507,152...45,529,164 		JBrowse link
G Srebf2 sterol regulatory element binding transcription factor 2 ISO RGD PMID:19933148 RGD:2317203 NCBI chr 7:115,542,774...115,600,945
Ensembl chr 7:115,543,290...115,600,943 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6091
    signaling pathway 2635
      transcription factor mediated signaling pathway 445
        basic helix-loop-helix signaling pathway 9
          sterol regulatory element-binding protein signaling pathway 7
Path 2
Term Annotations click to browse term
  pathway 6091
    regulatory pathway 3864
      pathway pertinent to DNA replication and repair, cell cycle, maintenance of genomic integrity, RNA and protein biosynthesis 1738
        transcription pathway 1059
          transcription pathway via transcription factor mediated signaling 445
            basic helix-loop-helix signaling pathway 9
              sterol regulatory element-binding protein signaling pathway 7
paths to the root